Understanding the role of the MYB oncogene in human breast cancer: targets and functions

Abstract

Breast cancer is one of top three diagnosed cancers in Australia and other countries.Approximately 64% of human breast cancers are oestrogen receptor positive (ER + ) and express the MYB oncogene. The MYB oncogene encodes a transcription factor (MYB) that regulates many cellular genes such as genes that are associated with cell proliferation, differentiation and apoptosis.