Understanding the significance of biological clock and its impact on cancer incidence

Malik, Shalie; Stokes, James; Manne, Upender; Singh, Rajesh; Mishra, Manoj K.

doi:10.1016/j.canlet.2021.12.006

Cited by 6 publications

(6 citation statements)

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“…Thus, a proper functioning of the circadian clock is critical to maintain homeostasis and physiological functions, and the perturbation of this system may result in severe pathologies including cancer 41,42 . Abnormal changes in circadian rhythms have been reported in jet lag 43 , night-shift workers 44 , cancer 45,46 , metabolic disorders 47,48 , mental disorders 49,50 , and also as a consequence of spaceflight [51][52][53] . Space travellers report circadian rhythm disruption during spaceflight, which is visible in many physiological aspects, for example shorter sleep durations 54 .…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

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The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth. Our analysis identified alterations of the clock network and skeletal muscle-associated pathways, as a result of spaceflight duration in mice, which resembles aging-related gene expression changes observed in humans on Earth (e.g., ATF4 downregulation, associated with muscle atrophy). Furthermore, according to our results, external factors such as exercise or fasting lead to molecular changes in the core-clock network, which may compensate for the circadian disruption observed during spaceflights. Thus, maintaining circadian functioning is crucial to ameliorate unphysiological alterations and musculoskeletal atrophy reported among astronauts.

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Section: Introductionmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

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“…Disruption of circadian rhythms can lead to various cancers 33 , including gastric cancer 14 . As a factor in cancer development, perturbation of the circadian rhythm affects the circadian homeostasis of energy balance, leads to changes in the cell cycle, and leads to dysregulation of chromatin remodeling 34 . However, knowledge gaps remain in our understanding of the relationship between biological clocks and cancer 34 .…”

Section: Relationship Between Biological Clock Genes and Immune Cell ...mentioning

confidence: 99%

Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer

Tian,

Xie,

Bai

et al. 2024

J Gastrointest Canc

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Background: Gastric cancer is one of the major public health problems worldwide. Circadian rhythm disturbances driven by circadian clock genes play a role in the development of cancer. However, whether circadian clock genes can serve as potential therapeutic targets and prognostic biomarkers for gastric cancer remains elusive.Methods: In this study, we comprehensively analyzed the potential relationship between circadian clock genes and gastric cancer using online bioinformatics databases such as GEPIA, cBioPortal, STRING, GeneMANIA, Metascape, TIMER, TRRUST, and GEDS.Results: Biological clock genes are expressed differently in human tumors. Compared with normal tissues, only PER1, CLOCK and TIMELESS expression differences were statistically signi cant in gastric cancer (p<0.05). PER1(P=0.0169) and CLOCK (P=0.0414) were associated with gastric cancer pathological stage (p<0.05). Gastric cancer patients with high expression of PER1 (p=0.0028) and NR1D1 (p=0.016) had longer overall survival, while those with high expression of PER1 (p=0.042) and NR1D1 (p=0.016) had longer disease-free survival. The main function of the biological clock gene is related to the circadian rhythm and Melatonin metabolism and effects. CLOCK, NPAS2 are KAT2B were a key transcription factor for circadian clock genes. In addition, we also found important correlations between circadian clock genes and various immune cells in the gastric cancer microenvironment.Conclusions This study may establish a new gastric cancer prognostic indicator based on the biological clock gene and develop new drugs for the treatment of gastric cancer using biological clock gene targets. | IntroductionGastric cancer is the fth most common cancer and the third most common cause of cancer death worldwide 1 . The pathogenesis of gastric cancer is a multi-step complex process caused by environmental and genetic factors. To date, although arti cial intelligence 2, 3 , big data 4 , and various omics 5 have been applied to the precise prevention and treatment of gastric cancer, the molecular mechanism behind the initiation, progression, and pathogenesis of gastric cancer is still unclear, which means that precise, effective and personalized treatment of gastric cancer is a promising strategy. Of note, even now, there is still a long way to go for precise prevention and treatment of gastric cancer. thus, it is very important to actively search for new molecular factors and clarify their biological functions and prognostic signi cance in gastric cancer.The biological clock is an invisible "clock" in the body, besides its main role as a circadian rhythm generator, the biological clock also plays a key role in controlling the physiological functions of almost all tissues and organs. It regulates multiple intracellular signaling pathways, ranging from cell proliferation 6 , DNA damage repair and response, angiogenesis 7 , metabolism 8 and redox homeostasis 9 , to in ammation 10 and immune responses 11 . Therefore, once the biological clock is disturbed, it will lead to

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“…Epidemiological studies have revealed many environmental factors could disturb circadian rhythms, such as shift work, sleep disruption, exposure to light at night, and jet lag. And disturbance of circadian rhythm is positively related to increased cancer risk and poorer cancer prognosis (Harding et al, 2022; Lunn et al, 2017; Malik et al, 2022; Papagiannakopoulos et al, 2016; Schwartz et al, 2022; Shafi et al, 2021; Wendeu‐Foyet & Menegaux, 2017). For instance, long‐term shift workers such as clinical nurses have a higher risk of breast cancer, particularly among women who performed shift work during young adulthood, when circadian rhythm and endocrine system are well‐developed (Wegrzyn et al, 2017).…”

Section: The Function Of Circadian Rhythm In Cancermentioning

confidence: 99%

“…Moreover, visually impaired people who are insensitive to changes in ambient light and largely rely on the internal biological clock to synchronize daily physiological activities, have a reduced overall risk of cancer (Kliukiene et al, 2001). Furthermore, defects or disruption in normal circadian functioning and altered levels of clock gene expressions can increase the risks of prostate cancers, breast cancers, ovarian cancers, colorectal cancers (CRC), endometrial cancers, non‐Hodgkin's lymphoma, pancreatic cancers, osteosarcomas, head and neck squamous cell carcinomas, acute myeloid leukemia, and hepatocellular carcinomas (HCCs) (Malik et al, 2022; Shafi et al, 2021).…”

Section: The Function Of Circadian Rhythm In Cancermentioning

confidence: 99%

“…Collectively, multiple nuclear receptors are closely involved in mammalian circadian clock machinery (Figure 3), forming a regulatory network for both central and peripheral clocks to precisely coordinate mammalian physiological activities with circadian rhythm (Figure 1). (Harding et al, 2022;Lunn et al, 2017;Malik et al, 2022;Papagiannakopoulos et al, 2016;Schwartz et al, 2022;Shafi et al, 2021;Wendeu-Foyet & Menegaux, 2017). For instance, long-term shift workers such as clinical nurses have a higher risk of breast cancer, particularly among women who performed shift work during young adulthood, when circadian rhythm and endocrine system are well-developed (Wegrzyn et al, 2017).…”

Section: Multiple Nuclear Receptors Form a Regulatory Network Of Circ...mentioning

confidence: 99%

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Circadian clock‐mediated nuclear receptors in cancer

Niu

Táng

2022

Journal Cellular Physiology

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Circadian system coordinates the daily periodicity of physiological and biochemical functions to adapt to environmental changes. Circadian disruption has been identified to increase the risk of cancer and promote cancer progression, but the underlying mechanism remains unclear. And further mechanistic understanding of the crosstalk between clock components and cancer is urgent to achieve clinical anticancer benefits from chronochemotherapy. Recent studies discover that several nuclear receptors regulating circadian clock, also play crucial roles in mediating multiple cancer processes. In this review, we aim to summarize the latest developments of clock-related nuclear receptors in cancer biology and dissect mechanistic insights into how nuclear receptors coordinate with circadian clock to regulate tumorigenesis and cancer treatment. A better understanding of circadian clock-related nuclear receptors in cancer could help prevent tumorigenesis and improve anticancer efficacy.

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Understanding the significance of biological clock and its impact on cancer incidence

Cited by 6 publications

References 251 publications

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer

Circadian clock‐mediated nuclear receptors in cancer

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