The article provides an overview of Ukrainian and foreign sources on the non-proliferation studies and interconnected with it problems of nuclear disarmament and the use of “peaceful” atom. We give little-known facts from the history of non-proliferation, attempts to put nuclear energy under effective international control and reasons why this could not be done. The main content of the article is an analysis of the NPT, IAEA and related international regimes and organizations, successes and failures in implementing the policy of non-proliferation. It is noted, on the one hand, maintaining a fairly steady non- proliferation regime since the entry into force of the NPT in 1970 – now there are only nine states with nuclear weapons, and this number remains unchanged over the past 25 years. NPT regime is almost universal – it includes 190 States Parties and only five remain outside (India, Israel, North Korea, Pakistan and South Sudan). However, according to some forecasts, increasing threat is likelihood of becoming world “widespread nuclear proliferation” in 2030. Features of positions of the US and Russia in matters of nonproliferation policy are studied.