Understanding venous malformations of the head and neck: a comprehensive insight

Colletti, Giacomo; Ierardi, Anna Maria

doi:10.1007/s12032-017-0896-3

Cited by 53 publications

(46 citation statements)

References 87 publications

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“…After reconstitution with normal saline, the manufacturer recommends that BTX-A should be stored in refrigerator (28C-88C) and used as soon as possible. 9 Storage beyond 4 hours after reconstitution has decreased the efficacy of BTX-A. 10,11 Some authors claimed that residual BTX-A could be stored in room temperature for 4 months without significant loss of activity.…”

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

“…12 Generally, 2 weeks of storage in refrigerator without freezing seems to be safe, not affecting the efficacy of BTX-A. 9,13 However, repeated usage of BTX-A after reconstitution is not recommended by manufacturer because of increased contamination risk. 9 Commercially available BTX-A is produced from bacteria or from eukaryotic cells.…”

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

“…9,13 However, repeated usage of BTX-A after reconstitution is not recommended by manufacturer because of increased contamination risk. 9 Commercially available BTX-A is produced from bacteria or from eukaryotic cells. The price for BTX-A is generally expensive.…”

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

“…[6][7][8] There are several options to treat VMs and these include sclerotherapy, surgery, or laser. 9 Overall, many descriptive studies are present in the literature regarding sclerotherapy. However, most focus on technical procedural aspects or short-term results only.…”

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confidence: 99%

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Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

Colletti

Deganello

Bardazzi³

et al. 2017

Journal of Craniofacial Surgery

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ô#and Francesco Stillo, MD ÃÃ Purpose: The aim of this study was to evaluate complications in patients with head and neck venous malformations (VMs) treated with foam sclerotherapy using sodium tetradecyl sulfate (STS). Methods: The authors retrospectively evaluated the complications, pain. and degree of satisfaction in 69 consecutive patients affected by cervicofacial VM managed with STS using the Tessari method in a single institution. Results: The average number of procedures for each patient was 2.1. The most frequent complication was blistering. We observed 1 patient of temporary weakness of a facial nerve branch, 1 paradoxical embolism, and 1 orbital compartment syndrome.The average pain score was 0 (no pain at all) (51.5%). There was no statistically significant correlation between patient satisfaction and the presence of complications or the degree of pain. Conclusions: Sclerotherapy with STS is an effective treatment that yields to very high patient satisfaction. This procedure has an overall low complication rate and is usually effective within a few sessions. However, severe complications may occur; these must be pointed out in the informed consent and the surgeon must be aware of and ready to quickly treat them to prevent long-term sequelae.Key Words: complication, endovascular, sclerotherapy, sodium tetradecyl sulfate, vascular malformation, venous malformation V ascular malformations are developmental abnormalities of the vascular tree present from birth. They are classified based on the vessel type (capillary, venous, lymphatic, and arteriovenous) or on their rheologic characteristics (slow-flow or fast-flow).1 Venous malformations (VMs) are the most common vascular malformation, and their treatment remains very challenging.2 Forty percent to 60% of all VMs involve the head and neck area. Symptoms may vary and include cosmetic complaints, pain, swelling, and functional limitations. Frequently, localized intravascular coagulopathy 3-5 can take place in larger VMs and will worsen signs and symptoms. In more ''benign'' patients, symptoms can be so mild that no treatment is needed, with the exception of conservative measures; in other patient, symptoms are so severe that >1 treatment can be needed and the approach has to be increasingly invasive. [6][7][8] There are several options to treat VMs and these include sclerotherapy, surgery, or laser. 9 Overall, many descriptive studies are present in the literature regarding sclerotherapy. However, most focus on technical procedural aspects or short-term results only. The conclusion in many articles is that VMs are difficult to treat and that most patients require multiple therapeutic sessions before a clinically relevant effect is obtained.Many sclerosants such as ethanol, jellified ethanol, bleomycin, polidocanol, or sodium tetradecyl sulfate (STS) are available, and they show an effectiveness of 74%, 89%, 88%, 90%, and 86%, respectively, according to a recent analysis. 6 Ethanol is one of the most commonly used, and is a potent agent for all types of va...

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Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

mentioning

confidence: 99%

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Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

Colletti

Deganello

Bardazzi³

et al. 2017

Journal of Craniofacial Surgery

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“…Most frequently, vascular lesions cause as small or large swelling on the tissue and show a bluish to purple discoloration on the tissue’s surface. These vascular lesions predominately affect the venous system [1-4], they are of benign nature, and around 50% of them are located on the head and neck region. When located on the face, they can produce a disfiguring aesthetic appearance [1-3].…”

Section: Introductionmentioning

confidence: 99%

Management of an Extensive Vascular Lesion on the Lip by Photocoagulation with High-Intensity Diode Laser

Azevedo¹,

Migliari²

2017

TODENTJ

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Objective:Extensive vascular malformations (VM) pose difficulties for an effective management.Introduction:This article describes a very satisfactory result, both functional and aesthetic, following a management by the technique of photocoagulation using diode laser in an extensive VM lesion involving the lower lip and left buccal mucosa in a 25 year old male.Case report:The patient reported that the lesion had been present since birth. The whole treatment, carried out under local anesthesia, spread over 6 months since as many as 4 sessions of laser, with a 1.5-month interval in each, were required. The resting period between sessions played an important part in treatment by allowing a time for the recovery of the patient and the shrinking of the lesion.Conclusion:The patient had no complications during the laser sessions, and his postoperative period was uneventful. No recurrence has been seen after a 2.5-year follow-up.

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Correlation between the miR‐618 rs2682818 C>A polymorphism and venous malformation susceptibility

Lin,

Chen,

et al. 2024

Biotech and App Biochem

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Venous malformations are the most common congenital vascular malformations, and the incidence rate is high. Previous studies have confirmed that a variety of polymorphisms within the miRNA functional region are associated with tumor susceptibility. We examined the correlation between miR‐618 rs2682818 C>A and risk of developing venous malformation in a southern Chinese population (1113 patients and 1158 controls). TaqMan genotyping of miR‐618 rs2682818 C>A was conducted utilizing real‐time fluorescent quantitative PCR. The miR‐618 rs2682818 polymorphism was not correlated with susceptibility to venous malformation (CA/AA vs. CC: adjusted odds ratio [AOR] = 1.00, 95% confidence interval [CI] = 0.81–1.25, p = 0.994; AA vs. CC/CA: AOR = 1.10, 95% CI = 0.73–1.65, p = 0.646). Stratified analysis of different subtypes of venous malformation revealed that there was no significant difference in the rs2682818 C>A polymorphism genotypes across these subtypes. Our results indicate that miR‐618 rs2682818 C>A polymorphism is not correlated with the susceptibility to venous malformation.

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Understanding venous malformations of the head and neck: a comprehensive insight

Cited by 53 publications

References 87 publications

Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

Management of an Extensive Vascular Lesion on the Lip by Photocoagulation with High-Intensity Diode Laser

Correlation between the miR‐618 rs2682818 C>A polymorphism and venous malformation susceptibility

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