Undescribed C-Glycosylflavones from Corn Silk and Potential Anti-inflammatory Activity Evaluation of Isolates

Sarfare, S; Khan, Shabana I.; Zulfiqar, Fazila; Radhakrishnan, S.; Ali, Zulfiqar; Khan, Ikhlas A.

doi:10.1055/a-1728-1347

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…Furthermore, in modern clinics, corn silk is applied to treat various diseases, such as nephritis, acute and chronic pneumonia, diabetes, hypertension, and edema [6]. In addition, many modern pharmacological activities, such as antihypertension activities [7], lowering blood lipids [8], anti-inflammatory activities [9], anti-urolithiasis activities [10], anti-oxidant activities [11], protecting the liver [12], and other effects [13] have been verified in previous studies.…”

Section: Introductionmentioning

confidence: 95%

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

Wang,

Mao,

Zhang

et al. 2024

Molecules

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Corn silk (Zea mays L.) is the stigma of an annual gramineous plant named corn, which is distributed in many regions worldwide and has a long history of medicinal use. In recent years, with the sustainable development of traditional Chinese medicine, studies of corn silk based on modern technologies, such as GC–MS, LC–MS, and other analytical means, have offered more comprehensive analyses. Phytochemistry studies have shown that the main bioactive components in corn silk include flavonoids, polyphenols, phenolic acids, fatty acids, and terpenoids. Pharmacological studies have shown that corn silk extract has various pharmacological effects, such as reducing blood lipids, lowering blood pressure, regulating blood sugar levels, anti-inflammatory effects, and anti-oxidation effects. In this paper, the related research on corn silk from the past few years is summarized to provide a theoretical reference for the further development and utilization of corn silk.

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Section: Introductionmentioning

confidence: 95%

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

Wang,

Mao,

Zhang

et al. 2024

Molecules

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“…Modern studies showed that corn silk owned diversiform ingredients, including flavonoids [17,18], polysaccharides [19,20], polyphenols [21], amino acids [22], and other components [23], among which flavonoids with antiinflammatory [24,25], antioxidant [26], and other helpful biological activities [27] were especially abundant. Our previous study has revealed that the main constituents absorbed into the blood of corn silk were flavonoids [28], indicating flavonoids may be the nominated material basis of pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical study: Fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk using high‐efficiency ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Wang,

Gu,

Mao

et al. 2023

Separation Science Plus

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Flavonoid‐C‐glycosides with various pharmacological actions were abundant in corn silk, and fragmentation in mass spectra of flavonoid‐C‐glycosides compounds was particularly important. This paper aimed to supervise the fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk by high‐efficiency ultra‐high‐performance liquid chromatography combined with a quadrupole time‐of‐flight mass spectrometry approach. Therefore, the flavonoids were extracted by heating reflux and then purified based on D101 macroporous resin. Thirty‐five flavonoids were triumphantly identified in the purified product. Among them, 14 were flavonoid‐C‐glycosides, seven of them owned luteolin mother nuclei (luteolin‐C‐glycosides) and seven of them owned apigenin mother nuclei (apigenin‐C‐glycosides). Importantly, the diagnostic product ions of luteolin‐C‐glycosides including m/z (431, 413, 395, 369, 367, 313, and 299) and m/z (429, 411, 393, 367, 365, 311, and 297), and the characteristic product ions of apigenin‐C‐glycosides covered m/z (353, 339, and 299) and m/z (339, 327, and 309). In addition, diagnostic H2O neutral loss and glycosyl craking were familiar, and the difference values among product ions mainly contained 40, 60, 70, 80, 90, 100, and 120 Da. Thus, the fragmentations of luteolin‐C‐glycosides and apigenin‐C‐glycosides identified in corn silk were with proper regularity. The obtained fragmentation patterns provided rapid recognition and meaningful guidance for the purification study of flavonoid‐C‐glycosides.

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Bioactive Potential of Baby Corn Silk: In-Vitro Evaluation of Antioxidant, Antimicrobial, Anti-diabetic, and Anti-gout Activities

Shankaranarayana,

Gajanana,

Chavan

et al. 2024

Waste Biomass Valor

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To analyse phytochemical composition, antioxidant potential, antimicrobial activity and α-amylase, αglucosidase and xanthine oxidase inhibitory potential of corn silk extracts derived from the Syngenta 5414 corn variety. MethodsCorn silk sample was lyophilized and extracted using 80% ethanol, methanol, water or acetone. Phytochemicals were qualitatively screened and bioactive compounds were identi ed through GCMS. Antimicrobial activities were evaluated using the agar well method for bacteria and fungal biomass method for fungi. The extracts were subjected to evaluation for their antidiabetic activity through α-amylase and α-glucosidase inhibitory assays, while their anti-gout potential was assessed through xanthine oxidase inhibitory assay, encompassing all four solvent extracts in the study. ResultsPhytochemical screening revealed the presence of phenols, avonoids, tannins, alkaloids, sterols, protein xanthoproteic, and cardiac glycosides in the extracts. The Folin-Ciocalteu and AlCl 3 assays demonstrated higher yields of phenolics and avonoids in 80% ethanolic extract. Furthermore, the extracts remarkably scavenged reactive oxygen species like DPPH, ABTS and elicited considerable ferric ion reducing antioxidant power. GC-MS analysis identi ed 21 compounds in the 80% ethanolic extract, with 1,2,3-Propanetriol-1-acetate, n-Hexadecanoic acid, and 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy-6-methyl-as major components. Antimicrobial assays demonstrated the ethanolic (80%) and methanolic extract's remarkable ability to inhibit the growth of Grampositive bacteria and exhibit anti-fungal properties. The ethanolic (80%) extract exhibited an IC 50 value of 0.70 ± 0.02 and 0.71 ± 0.01 mg against α-amylase and α-glucosidase, respectively, and 33.76 ± 0.43 mg against xanthine oxidase. ConclusionCorn silk exhibits potential as a valuable reservoir of natural bioactive compounds endowed with a wide array of health-promoting properties. HighlightsThe study highlights the signi cance of natural by-products in modern medicine and emphasizes the importance of multidisciplinary research in unlocking their full potential for human health and well-being.The study emphasizes the signi cance of exploring most suitable extraction solvent for speci c sample types and the exhibited biological activities.The outcomes contribute to the understanding of corn silk's phytochemical composition and provide scienti c support for its traditional use in the management of diabetes mellitus and gout.The study bridges the gap between traditional knowledge and modern scienti c insights, rea rming the potential value of traditional medicine in addressing contemporary health challenges.

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Undescribed C-Glycosylflavones from Corn Silk and Potential Anti-inflammatory Activity Evaluation of Isolates

Cited by 8 publications

References 25 publications

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

Phytochemical study: Fragmentation patterns of flavonoid‐C‐glycosides in the enriched flavonoids from corn silk using high‐efficiency ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Bioactive Potential of Baby Corn Silk: In-Vitro Evaluation of Antioxidant, Antimicrobial, Anti-diabetic, and Anti-gout Activities

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