Undiagnosed acute HIV infection identified through RNA testing of pooled serum samples obtained during a dengue outbreak in São Paulo, Brazil

Matsuda, Elaine Monteiro; Colpas, Daniela Rodrigues; Campos, Norberto Camilo; Coelho, Luana Portes Ozório; Carmo, Andréia Moreira dos Santos; Brígido, Luis Fernando de Macedo

doi:10.1590/0037-8682-0370-2016

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…Due to the content of phenolic compounds (eugenol) they may also show chemopreventive activity and affect the induction of cancer cell apoptosis [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

Makuch¹,

Nowak²,

Günther³

et al. 2020

Preprint

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The main focus of this work is to extend the knowledge about the complexity of issues of oxidative stress. Natural compounds play a serious role in multiple aspects of both human, leading to clear health-promoting effects. This work is focused on the potential application cosmetic formulations containing including but not limited to of clove water and isolated clove oils on their aid in the control of the diseases. The aim of our work was to prepare to evaluate cosmetic formulations containing clove oil, eugenol or new eugenol ester derivative (eugenyl dichloroacetate - EDChA) but also cosmetic formulations containing the aqueous phase obtained after separation of essential oil following the clove buds steam distillation. To evaluate the antioxidants transdermal delivery system, in vitro permeation experiments in a Franz diffusion cell were performed using pig skin. The antioxidative capacity of the cosmetic formulations obtained was determined by the DPPH free radical reduction method. In the next stage, the antioxidant activity (DPPH, ABTS, and Folin–Ciocalteu methods) of the fluid that penetrated through pig skin and of the fluid obtained after skin extraction, were also evaluated. For comparison, studies of cosmetic formulation containing alone dichloroacetic acid (DChAA) were as well carried out. The obtained cosmetic formulations were characterized by of antioxidant activity estimated after 24 hours of conducting the experiment, which indicates long-term protection against reactive oxygen species (ROS) in the deeper layers of the skin. The results of this work contribute to the development of cosmetic formulations with antioxidant potential, emphasizing that the water phases are waste from the process of cloves steam distillation and are not used to prepare cosmetic formulations. The use of waste water from the clove buds steam distillation process is environmentally friendly and not allows us to waste, containing however valuable biologically active compounds (furfural, methyl salicylate, 4-allilofenol, eugenol, α- and β-caryophyllene, eugenyl acetate, β-caryophyllene oxide). Together, these results suggest that cosmetic formulations may be potential drug candidates for chemopreventive, antineoplastic and antimutagenic therapy.

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Section: Discussionmentioning

confidence: 99%

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

Makuch¹,

Nowak²,

Günther³

et al. 2020

Preprint

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show abstract

“…This strategy was evaluated during a dengue outbreak in Brazil, where investigators analyzed pooled samples of seronegative dengue cases for HIV RNA [ 14 ]. An HIV-1 prevalence of 0.73% was found.…”

Section: Discussionmentioning

confidence: 99%

High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore

Verrall

Lye

Pada

et al. 2018

Open Forum Infectious Diseases

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“…CD8+ T cells produce perforin and granzyme to provide protection against viral infection, resulting in a decline in the viral load. 9 During the latent phase, the CD4+ cell count continues to decline while the viral count rises but the patient usually remains asymptomatic. This latent stage can last as long as 10-15 years among HIV patients and, while the patient is clinically asymptomatic, the virus is exceptionally versatile.…”

Section: Hiv Pathogenesismentioning

confidence: 99%

Liposomal-Glutathione as a Potential Therapeutic Agent to Control HIV-1 Infection and Tuberculosis

Robinson

Munjal

D'Agostino

et al. 2018

EMJ Allergy Immunol

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This literature review provides insights into how glutathione (GSH) plays an important role in controlling HIV-1 and Mycobacterium tuberculosis infections. Since the discovery of HIV in 1981, >40 million affected individuals have died due to AIDS, and currently 40 million people are infected with HIV worldwide, which primarily infects CD4+ T cells. The natural pathogenesis of HIV consists of three stages: 1) the primary HIV infection phase, 2) the asymptomatic chronic phase, and 3) the late HIV symptomatic phase, which leads to an immunocompromised state resulting in increased susceptibility to opportunistic infections. It has been shown that HIV+ individuals have low levels of GSH; increased levels of proinflammatory cytokines, which correlate with increased production of reactive oxygen species and oxidative stress; and increased levels of TGF-β compared to healthy individuals. Consequently, increased reactive oxygen species levels lead to decreased levels of reduced GSH and increased levels of TGF-β, which has been demonstrated to inhibit the rate-limiting enzyme responsible for the de novo synthesis of GSH. In addition, the authors demonstrate that with supplementation of reduced GSH, there is improved intracellular control of an M. tuberculosis infection within macrophages. Therefore, decreased levels of GSH can leave HIV+ individuals prone to such opportunistic infections. The HIV transactivator of transcription (TAT) protein has also been shown to further increase oxidative stress and reduce GSH levels. Liposomal-GSH supplementation has the ability to bypass de novo GSH synthesis and provide protection against HIV and M. tuberculosis infections by increasing levels of GSH, improving redox homeostasis, and dampening the effects of TGF-β.

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Undiagnosed acute HIV infection identified through RNA testing of pooled serum samples obtained during a dengue outbreak in São Paulo, Brazil

Cited by 7 publications

References 8 publications

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative

High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore

Liposomal-Glutathione as a Potential Therapeutic Agent to Control HIV-1 Infection and Tuberculosis

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