Undifferentiated carcinoma of nasopharyngeal type in children: Clinical features and outcome

Zrafi, Wael Salem; Tebra, Sameh; Tbessi, S.; Ouni, S.; Jebsi, M.; Bouaouina, Noureddine

doi:10.1016/j.anorl.2017.03.002

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…A higher T stage has been reported as an unfavorable factor for survival (27,34). In the present study, higher plasma EBV DNA and T4 category were independent predictors for DMFS and DFS.…”

Section: Discussionsupporting

confidence: 59%

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Qiu

Guo

et al. 2020

Front. Oncol.

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“…A higher T stage has been reported as an unfavorable factor for survival (27,34). In the present study, higher plasma EBV DNA and T4 category were independent predictors for DMFS and DFS.…”

Section: Discussionsupporting

confidence: 59%

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Qiu

Guo

et al. 2020

Front. Oncol.

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“…Zrafi WS et coll. [17] quant à eux retrouvaient 90% de masses cervicales, c'est le cas aussi de Ndiaye IC et coll. [18] avec des adénopathies dans 73.33% des cas.…”

Section: Discussionunclassified

Cancers ORL chez les enfants et adolescents au service d’ORL du CHNU de FANN (A propos de 65 cas)

BARRY,

Al.

2023

DKM

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introduction: Every year, more than 400,000 cancers are diagnosed in children and adolescents aged 0-19 [1,3]. In the specific case of head and neck cancer in pediatric patients, the worldwide prevalence is still unknown [7]. New data are therefore needed to improve their management.objectives: To analyse the epidemiological aspects of ENT cancers in patients aged 0-18 years.patients and methods: This was a retrospective, descriptive, single-centre study. It concerned children aged 0-18 years hospitalized for ENT cancer between 1 June 2010 and 30 June 2020. The term «ENT cancer» was used to designate cancers of the VADS, ear, main salivary glands and thyroid, as well as malignant adenopathies of primary appearance and cervico-facial lymphomas.results: A total of 65 patients were identified, representing a frequency of 1.94%. The sex ratio (M/F) was 1.40. The mean age was 13 years, with extremes of 2 and 18 years. 78.46% of patients were over 10 years old. The average consultation time was 7 months, with extremes of 1 month and 60 months, and 63.92% of patients consulted before 6 months. Cervical masses accounted for 69.23% of consultations. No previous history was found in 80% of our patients. The cavum was found in 40% of cases and the hypopharynx in 21.54%. Squamous cell carcinoma was found in 49.23% of cases and lymphoma in 13.85%. Patients presenting at stage T3 or T4 represented 61.54% of cases. Excisional surgery was performed in 6.16% of cases and chemotherapy in 24.61%. 50.77% of patients were lost to follow-up and 43.08% died after an average follow-up of 10 months. Conclusion: ENT cancers in children and adolescents are rare but have a poor prognosis. Improving our technical facilities and raising public awareness could eventually improve the prognosis.

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“…Neck mass was the most prevalent impetus to seek treatment, as shown in previous studies. 7,9,19 A study in China reported that neck mass affected up to 40.9% of pediatric patients and cranial nerve involvement in 3% patients. 7 This percentage was lower than in our study (Table 2), but neck mass was the most common symptom.…”

Section: Discussionmentioning

confidence: 99%

“…6 Common symptoms in pediatric patients are neck masses, blocked nose, and hearing problems. [7][8][9] These symptoms are sometimes regarded as other diseases and, therefore, misdiagnosed. Owing to their locoregional mass extension, some patients present with cranial nerve palsies causing diplopia, trismus, as well as facial numbness and pain.…”

mentioning

confidence: 99%

Epstein-Barr DNA in advanced pediatric nasopharyngeal cancer

Adham

Jelita

Gatot

et al. 2021

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Background Studies suggest that the most common type of nasopharyngeal carcinoma (NPC) is WHO-3, which is strongly associated with Epstein-Barr virus (EBV). Objective To assess NPC patient characteristics in a national general referral hospital in Indonesia, with regards to EBV DNA load and treatment response. Methods Twenty-three pediatric patients diagnosed with NPC were included in the study. Data collected were history, physical examination, tissue biopsy, CT scan, staging and EBV DNA load from nasopharyngeal (NP) brushing as well as blood specimens. The NP brushing, blood specimens and CT scan evaluations were done two months post-treatment. Results Pediatric patients with symptoms such as blood tinged secretion, lymph node enlargement, and nasal congestion were more likely to have higher EBV DNA loads in their NP brushings (P<0.05) (including T3 and higher). Despite significant reduction of EBV DNA load in NP brushing post-treatment, it was not associated with treatment response, as evaluated by CT scan. Conclusion Higher DNA load from NP brushings is associated with a higher tumor stage. Larger sample size and follow-up data are needed to assess the usefulness of EBV DNA load assessment in pediatric patients.

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Undifferentiated carcinoma of nasopharyngeal type in children: Clinical features and outcome

Abstract: Undifferentiated carcinoma of nasopharyngeal type in children represents 6% of all cases of UCNT managed in our institutions. It is often discovered at an advanced stage. Sequential treatment combining chemotherapy and radiotherapy achieves an excellent local control rate.

Cited by 8 publications

References 11 publications

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Cancers ORL chez les enfants et adolescents au service d’ORL du CHNU de FANN (A propos de 65 cas)

Epstein-Barr DNA in advanced pediatric nasopharyngeal cancer

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