Undifferentiated Carcinoma with Lymphoid Infiltration of the Esophagus: a Case Report

Abstract

This paper reports a surgically treated case of undifferentiated carcinoma with lymphoid infiltration of the esophagus. Histologically, most of the tumor consisted of undifferentiated carcinoma (non-small cell type) with lymphoid infiltration and a small portion showed features of poorly differentiated squamous cell carcinoma. Carcinoma with lymphoid infiltration in the stomach, breast or nasopharynx has a good prognosis, but in the esophagus this histological type is extremely rare and its characterization is unclear. This is only the sixth report to date of undifferentiated carcinoma with lymphoid infiltration of the esophagus.

A case study of rare lympho-epithelioma like esophageal carcinoma

“…Exceptional cases may have simple ulcerative morphology, polypoid lesion, or solely reddish mucosal irregularity in our case, the lesion was polypoid and the accompanying reddish mucosal irregularity was established from the lesion to the level of the cardioesophageal junction [10]. The role of diffuse infiltrating lymphocytes, consisting of a large number of T lymphocytes and a small number of B lymphocytes, has not yet been clarified in LELC.…”

“…Burke first detected EBV DNA in gastric cancer that histologically resembled nasopharyngeal lymphoepithelioma and after that several reports also demonstrated a close relationship between that type of gastric cancer and EBV. However, there does not appear to be a relationship between esophageal cancer and EBV [10].…”

“…LELC was first reported by Bégin et al in 1987 [10]. LELC is defined as a tumor with histological similarity to undifferentiated nasopharyngeal carcinoma with lymphoid stroma, and this condition has been described in various organs.…”

“…Esophageal LELC are primarily submucosal lesions with nor mal-appearing epithelial coverage and rarely can have polyp oid, ulcerative, or reddish mucosal irregularity [8]. The prognosis of patients suffering from this type of cancer has been reported to be favorable [10].…”

Multimodality Therapy Is Recommended for Limited-Stage Combined Small-Cell Esophageal Carcinoma

“…2,5,9,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] The baseline characteristics of all patients are shown in Table 1. The characteristics of patients from our institution are summarized in Table 2.…”