Undifferentiated tumor in the ovary of a corn snake (<i>Elaphe guttata guttata</i>)

Petterino, Claudio; Bedin, Marco; Podestà, Giorgia; Ratto, Alessandra

doi:10.1111/j.1939-165x.2006.tb00095.x

Cited by 16 publications

(11 citation statements)

References 28 publications

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“…These results were used to characterize and classify the neoplasm as malignant tumor of the peripheral nerve sheath. In the work of Petterino et al (2006), conducting molecular studies of a neoplasm of spindle cell pattern of the corn snake (Elaphe guttata guttata), suggesting sarcoma, it was essential to define the epithelial origin of the neoplasm, through the expression of the marker AE1/AE3, confirming the diagnosis of undifferentiated carcinoma of the ovary. The examination showed positive immunostaining for smooth muscle actin, skeletal muscle actin and cytokeratin (AE1/AE3) and there was no labeling for vimentin and desmin.…”

Section: Discussionmentioning

confidence: 99%

Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

et al. 2015

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RESUMO.-[Fibrossarcoma oral em jararaca (Bothrops pubescens): aspectos anatomopatológicos e imuno-histoquímicos.] Uma serpente de cativeiro, fêmea, quatro anos de idade, do gênero Bothrops apresentou aumento de volume no lado esquerdo da cavidade oral, sugerindo tratar--se de neoplasma. A massa foi removida cirurgicamente e enviada para exame anatomopatológico. Dois meses depois foi observado novo aumento de volume no mesmo local, sugerindo recidiva. A lesão foi removida por completo e também enviada para análise. Histologicamente, as duas amostras consistiam de massa altamente celular, composta por células anaplásicas fusiformes organizadas em feixes entrelaçados e distribuídos por toda extensão tecidual e, ocasionalmente, células poligonais arranjadas em fascículos irregulares. A coloração de tricrômico de Masson apresentou quantidade modesta de colágeno sustentando as células neoplásicas. Não foi observado conteúdo PAS-positivo no citoplasma das células neoplásicas. Os achados histológicos e histoquímicos indicavam tratar-se de neoplasma de célu-las fusiformes, porém não era possível sua classificação. A E-mail: acmotta@upf.br A 4-year-old female captive-bred snake of the genus Bothrops showed swelling on the left side of the oral cavity, suggesting the development of neoplasia. The mass was removed surgically and sent for pathological examination. Two months later a new increase in volume in the same site was observed, suggesting recurrence. The lesion was completely removed and sent for pathological analysis. Histologically, the two-samples consisted of a mass with highly-cell density composed of spindle-shaped anaplastic cells arranged in interwoven bundles, distributed throughout the tissue extension and, occasionally, polygonal cells arranged in irregular fascicles. The Masson trichrome staining showed modest amount of collagen supporting the neoplastic cells. PAS-positive content was not observed in the cytoplasm of neoplastic cells. Histological and histochemical findings indicated that it was a spindle cell neoplasm, but the classification was not possible. Immunohistochemistry was requested and performed using the streptavidin-biotin-peroxidase method. The markers used were anti-vimentin, anti-PCNA, anti-EMA, anti-melan A and anti-melanosome, anti--desmin, anti-actin, anti-CD68 and anti-S100protein. The neoplastic cells were immunoreactive for vimentin and PCNA and negative for the other antibodies. The morphology characterization, histochemical and immunohistochemical analysis of neoplastic cells allowed the definitive diagnosis of oral fibrosarcoma. Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects imuno-histoquímica foi requisitada e realizada pelo método streptavidina-biotina-peroxidase, utilizando os anticorpos anti-vimentina, anti-PCNA, Anti-EMA, anti-melan A, anti--HMB45, anti-desmina, anti-actina, anti-CD68 e anti-proteí-na S-100. As células neoplásicas foram imunorreativas para vimentina e PCNA e, negativas para os demais anticorpos. A ca...

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Section: Discussionmentioning

confidence: 99%

Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

et al. 2015

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“…Ovarian neoplasms have been reported in different species including reptiles [ 2 – 4 ], but among them malignant teratomas are reported as rare. Previously reported ovarian tumors in green iguanas, include teratomas [ 5 , 6 ], one adenocarcinoma [ 7 ], and one papillary cystadenocarcinoma [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and surgical management of malignant ovarian teratoma in a green iguana (Iguana iguana)

Bel¹,

Tecilla²,

Borza³

et al. 2016

BMC Vet Res

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BackgroundOvarian tumors in reptiles are uncommonly reported in the literature and for green iguanas previously reported cases include teratomas, one adenocarcinoma and one papillary cystadenocarcinoma. The present report is the first of a malignant ovarian teratoma in a green iguana. Complete and detailed pathological features, differential diagnosis and surgical management of malignant ovarian teratoma are discussed in this paper.Case PresentationA 9-year-old intact female green iguana (Iguana iguana) with a clinical history of persistent anorexia and progressive abdominal distension was referred to the surgery department. On physical examination, a presumptive diagnosis of follicular stasis was established. Radiographic evaluation showed a large radioopaque mass within the abdomen, which was visible both in latero-lateral and ventro-dorsal exposures. Abdominal ultrasonography showed a large intra-abdominal mass, with numerous cyst-like structures filled with liquid and a heterogeneous aspect with hypoechoic areas. Exploratory laparatomy was thus suggested and the mass was removed surgically. The histologic findings of the neoplasm were consistent with those of ovarian malignant teratoma. Surgical excision of the mass in our case was considered curative and after a follow-up period of 6 months the animal has recovered completely.ConclusionsA malignant ovarian teratoma has not been previously reported in green iguana and should be included in the list of differential diagnosis of ovarian tumors in this species. This report will contribute to a better understanding of the pathology of this rare tumor in green iguanas.

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“…This case also demonstrates the successful use of immunohistochemistry staining in the identification of metastases, a tool that is infrequently utilized despite having shown promise in the past. 7 A captive 16-yr-old female northern water snake kept at a wildlife center presented for examination of a midcoelomic mass noted approximately 3 days prior to presentation to the Exotics and Zoological Medicine Service at The Veterinary Health Center, Kansas State University. The mass was oval shaped, immobile, and firm.…”

Section: Brief Communicationmentioning

confidence: 99%

SPLENOPANCREATIC DUCTAL ADENOCARCINOMA WITH MULTIORGAN METASTASIS IN A NORTHERN WATER SNAKE (NERODIA SIPEDON)

Matthews¹,

Eshar²,

Delk³

et al. 2014

Journal of Zoo and Wildlife Medicine

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A 16-yr-old northern water snake (Nerodia sipedon) presented with a large, firm midcoelomic swelling. A complete blood count, survey radiographs, coelomic ultrasound, and fine needle aspirate of the mass were performed. Survey radiographs revealed a soft tissue opacity mass. Ultrasonographic examination confirmed the presence of the mass but could not aid in its visceral localization. After 2 weeks, the snake presented again because of continued anorexia and poor quality of life. Euthanasia was performed. Gross necropsy revealed a multilobulated mass attached to and effacing the splenopancreas. Histologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells forming tubules surrounded by variable amounts of fibrovascular stroma. Histological examination and immunohistochemical staining of other tissues revealed local invasion in the subserosa and tunica muscularis of the stomach, metastasis within the liver, in the mesovarium, and an intravascular metastasis within the ventricle of the heart surrounded by a thrombus.

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Undifferentiated tumor in the ovary of a corn snake (Elaphe guttata guttata)

Cited by 16 publications

References 28 publications

Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

Diagnosis and surgical management of malignant ovarian teratoma in a green iguana (Iguana iguana)

SPLENOPANCREATIC DUCTAL ADENOCARCINOMA WITH MULTIORGAN METASTASIS IN A NORTHERN WATER SNAKE (NERODIA SIPEDON)

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