Une cause rare de neuropathie optique : le manioc

Zéboulon, Pierre; Vignal-Clermont, C.; Baudouin, Christophe; Labbé, Antoine

doi:10.1016/j.jfo.2016.02.009

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Our study is most consistent with a prior study by Zebulon et al that described 10 patients with central or caecocentral scotoma and bilateral temporal RNFL loss on OCT, presumed secondary to cassava toxicity. 3 Patients experienced an onset of visual symptoms with an average of 22.7 years after consuming a mean of 2.57 cassava-based meals per week. OCT-RNFL showed marked temporal thinning in all patients with preservation of other sectors, consistent with our cases.…”

Section: Discussionmentioning

confidence: 99%

“…2 Reports on cassava root-induced toxicity involving solely the optic nerve are few, but describe decreased visual acuity (VA) and colour vision and optic atrophy. 3 Although optic neuropathy from cassava has been reported previously, this is the first report to our knowledge that identifies the particular patterns of retinal nerve fibre layer (RNFL) loss on optical coherence tomography (OCT) and retinal ganglion cell (RGC) complex changes in a non-consanguineous couple.…”

Section: Introductionmentioning

confidence: 86%

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Rare Optic Neuropathy in a Jamaican Couple Linked to Cassava Root Consumption

Akella

Ben-David

Schultz

et al. 2018

Neuro-Ophthalmology

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We report central visual loss with selective papillomacular bundle damage in a Jamaican couple, husband and wife, with long-term cassava root consumption. The two cases presented independently with gradual central visual loss. Examination revealed bilateral temporal pallor of the optic nerve head and automated static perimetry demonstrated a central or caecocentral scotoma in each patient. Optical coherence tomography findings are described. The only mutual risk factor, reported independently, was long-term cassava consumption. Cessation of cassava intake and vitamin supplementation resulted in partial recovery of visual function. As thiocyanate levels in urine were not measured, the aetiology in these patients is not definitively confirmed, but chronic cassava consumption should be considered in similar cases as a rare cause of potentially reversible optic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%