Une curieuse tumeur digestive à cellules rondes

Zehani, Alia; Chelly, Inès; Chelly, Beya; Coindre, Jean‐Michel; Haouet, Slim; Kchir, Nidhameddine

doi:10.1016/j.annpat.2014.02.013

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Ki67 is one of the most extensive cell proliferation markers which can be expressed at all stages of the cell cycle except in the G0 phase. 22 The IL-6 inhibitor group had lower Ki67 positive cells than the control groups, indicating that inhibiting the IL-6/STAT3/HIF-1α pathways could suppress IH cell proliferation.…”

Section: Discussionmentioning

confidence: 88%

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

et al. 2022

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Objective This study aims to evaluate the expression of interleukin 6 (IL-6) in patients with infantile hemangioma (IH) and investigate the role of the IL-6/signal transducers and activators of transduction-3 (STAT3)/hypoxia-inducible factor-1α (HIF-1α) pathways in the progression of IH. Methods Serum samples were obtained from the patients with IH and normal infants to measure IL-6 expression. Hemangioma-derived stem cells (HemSCs) were transfected with small interfering RNA (siRNA) targeting IL-6, HIF-1α, or STAT3. Then, cell viability and wound healing assays were conducted. After that, the HemSC tumor mouse model was established. The in vivo anticancer effect of the IL-6 inhibitor was investigated. Results The patients with IH had much higher IL-6 levels compared with the healthy controls (p = 0.005). HemSCs transfected with IL-6 siRNA had significantly lower viability and migration rates than normal HemSCs. HemSCs transfected with STAT3 siRNA or HIF-1α siRNA had similar tendencies. On tumor-bearing mice, the IL-6 inhibitor treatment significantly delayed tumor growth. Compared with the control group, caspase-3 was significantly increased in the IL-6 inhibitor group (p < 0.05), whereas Ki-67 was decreased in the IL-6 inhibitor group (p < 0.05). In the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, the IL-6 inhibitor group had much higher apoptosis rates than the controls (p < 0.05). Conclusion Our findings indicate that inhibiting the IL-6/STAT3/HIF-1α signaling pathways could suppress IH growth.

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Section: Discussionmentioning

confidence: 88%

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

et al. 2022

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“…Ki-67 expression can be detected in cells by immunohistochemistry and is considered a biomarker re ecting tumor cell proliferation and predicting prognosis [23]. Previous studies have found [24] that Ki-67 proliferation index showed a signi cant increase from WHO grade I to WHO grade II, which may provide useful prognostic information, which is similar to the ndings that Ki-67 proliferation index of AtM was signi cantly higher than that of TrM in this study, and tumor cell proliferation activity increased with Ki-67 proliferation index. In this study, we also found that parameters such as variance, skewness, kurtosis, ADCp90, and ADCp99 were signi cantly negatively correlated with Ki-67, and Surov et al [25]…”

Section: Pearson Correlation Between Adc Histogram Parameters and Ki-...mentioning

confidence: 99%

ADC histogram parameters differentiating atypical from transitional meningiomas: correlation with Ki-67 proliferation index

Han,

Liu,

Jing

et al. 2023

Acta Radiol

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Background Preoperative differentiation of atypical meningioma (AtM) from transitional meningioma (TrM) is critical to clinical treatment. Purpose To investigate the role of apparent diffusion coefficient (ADC) histogram analysis in differentiating AtM from TrM and its correlation with the Ki-67 proliferation index (PI). Methods Clinical, imaging, and pathological data of 78 AtM and 80 TrM were retrospectively collected. Regions of interest (ROIs) were delineated on axial ADC images using MaZda software and histogram parameters (mean, variance, skewness, kurtosis, 1st percentile [ADCp1], 10th percentile [ADCp10], 50th percentile [ADCp50], 90th percentile [ADCp90], and 99th percentile [ADCp99]) were generated. The Mann–Whitney U test was used to compare the differences in histogram parameters between the two groups; receiver operating characteristic (ROC) curves were used to assess diagnostic efficacy in differentiating AtM from TrM preoperatively. The correlation between histogram parameters and Ki-67 PI was analyzed. Results All histogram parameters of AtM were lower than those of TrM, and the variance, skewness, kurtosis, ADCp90, and ADCp99 were significantly different ( P < 0.05). Combined ADC histogram parameters (variance, skewness, kurtosis, ADCp90, and ADCp99) achieved the best diagnostic performance for distinguishing AtM from TrM. Area under the curve (AUC), sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 0.800%, 76.25%, 67.95%, 70.15%, 70.93%, and 73.61%, respectively. All histogram parameters were negatively correlated with Ki-67 PI (r = −0.012 to −0.293). Conclusion ADC histogram analysis is a potential tool for non-invasive differentiation of AtM from TrM preoperatively, and ADC histogram parameters were negatively correlated with the Ki-67 PI.

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Une curieuse tumeur digestive à cellules rondes

Cited by 2 publications

References 4 publications

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

ADC histogram parameters differentiating atypical from transitional meningiomas: correlation with Ki-67 proliferation index

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