Une tumeur du sein inhabituelle : le carcinome endocrine mammaire primitif

Boufettal, Houssine; Noun, M.; Mahdaoui, Sakher; Hermas, S.; Samouh, N.

doi:10.1016/j.femme.2011.01.005

Cited by 5 publications

(19 citation statements)

References 8 publications

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“…No clinical signs are specific to these tumors [8,9]. These tumors are characterized by a slow evolution and the most frequent reason for consultation is an isolated breast nodule or a breast nodule associated with other signs [8]. Our cases illustrate these features that are reported in the literature.…”

Section: Discussionsupporting

confidence: 57%

“…An Octreoscan and a positron emission tomography (PET) scan should rule out primary sites: ears, nose, and throat (ENT), lungs, digestive, and cutaneous [2,7]. No clinical signs are specific to these tumors [8,9]. These tumors are characterized by a slow evolution and the most frequent reason for consultation is an isolated breast nodule or a breast nodule associated with other signs [8].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary neuroendocrine tumors of the breast: two case reports and review of the literature

Hejjane¹,

Oualla²,

Bouchbika³

et al. 2020

J Med Case Reports

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Background: Neuroendocrine carcinomas mainly affect the bronchopulmonary and the gastrointestinal systems. Breast localizations are very rare. They represent less than 0.1% of all breast cancers. A definitive diagnosis relies on histological and immunohistochemical examinations. Case presentation: Case 1 We report a case of primary neuroendocrine carcinoma of the breast in a 71-year-old Arabic woman who presented with a 3 cm palpable and mobile tumor of the right breast. Clinical and radiological assessment excluded any other primary tumor. Radical mastectomy and axillary lymph node resection were performed. A histopathological examination disclosed the diagnosis of primary breast neuroendocrine tumors, with negative surgical margins and lymph nodes (18 N-/18 N). The tumor cells were positive for neuroendocrine markers, a weak Ki-67 proliferation index and negative Her2/neu. Our patient received adjuvant hormonal treatment with antiaromatase for 21 months. She is on regular follow-up, and she remains free of disease to date. Case 2 A 48-year-old Arabic woman consulted for a right breast nodule. She underwent lumpectomy with right axillary lymphadenectomy. The diagnosis was breast neuroendocrine tumor. Systemic treatment was proposed, but she was lost to follow-up. She consulted 1 year later for a mass in the same breast. A histological and immunohistochemical examination of a mammary biopsy was consistent with a recurrence of the previous neuroendocrine tumor. A radiological assessment showed a large mass in her right breast, ipsilateral axillary lymphadenopathies, and hepatic and pulmonary metastases. She received first-line metastatic chemotherapy, with good clinical and radiological improvement. She refused the mastectomy and was given hormone therapy. One year later, the tumor expanded clinically and radiologically, and she underwent second-line metastatic chemotherapy, with good clinical progress and radiological stability, and she then underwent maintenance hormonal therapy. Conclusion: Due to the rarity of primary breast neuroendocrine tumors, no standard therapy exists and the prognosis remains difficult to determine. Studies, including larger series, are needed in order to understand the biological behavior of these tumors.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine tumors of the breast: two case reports and review of the literature

Hejjane¹,

Oualla²,

Bouchbika³

et al. 2020

J Med Case Reports

View full text Add to dashboard Cite

show abstract

“…La palpation d'un nodule du sein isolé, bien circonscrit, de petite taille, sans signes inflammatoires ni adénopathie axillaire palpable est la circonstance de découverte la plus fréquente dans notre série ainsi que dans la plupart des cas de la littérature [9,10]. Les tumeurs de forme solide, souvent rondes et bien limitées, peuvent être confondues cliniquement avec des lésions bénignes du sein [11].…”

Section: éTude Clinique Et Diagnostic Positifunclassified

“…Cependant, Gunhan-Bilgen et al ont décrit que les signes radiologiques communs des tumeurs neuroendocrines primitives du sein étaient une masse de haute densité avec des marges principalement spiculées ou lobulées sur la mammographie [14]. Les microcalcifications sont moins fréquente dans les tumeurs neuroendocrines primitives du sein que dans les autres carcinomes mammaires [10,13].…”

Section: éTude Clinique Et Diagnostic Positifunclassified