Une ulcération génitale

Schambach, S.; Sirvain, S.; Fraisse, T.

doi:10.1016/j.revmed.2014.01.001

Cited by 2 publications

(2 citation statements)

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“…Most cutaneous ulcerations were located on the leg (60%), and other sites were the scalp, chest , abdomen, fingers, genitals and feet. Most patients (78·4%) had a single ulcerative lesion, although some patients had more than three lesions . A seriousness criterion was mentioned in 87 cases (58·8%).…”

Section: Resultsmentioning

confidence: 99%

“…Over the 10‐year period, 148 cases of confirmed nicorandil‐induced ulcerative lesions were identified, 108 of them located on mucous membranes, 32 on skin and 8 on both mucosal and cutaneous sites (Figure ). Seven had been published in the literature . Patients included 76 females and 72 males aged 80·0 ± 7·6 years old and 76·6 ± 10·6 years old, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Nicorandil‐induced ulcerations: a 10‐year observational study of all cases spontaneously reported to the French pharmacovigilance network

Babic

Petitpain²,

Guy

et al. 2018

International Wound Journal

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Nicorandil-induced ulcers remain often poorly recognised, with a late diagnosis and an inadequate management. We aimed to provide a clinical overview of the 148 spontaneously reported cases of nicorandil-induced ulcers to the French pharmacovigilance network between 2005 and 2014 and to complete this picture with worldwide published cases over the same period. Spontaneously reported nicorandil-induced ulcers were mainly mucosal (oral and anal) with a previous trauma in 23·0% of patients, revealed by a severe complication in 12·8% of cases. The mean cumulative dose of nicorandil was higher in serious cases. The median delay between the start of nicorandil use and the onset of the ulcer was 23·4 months, and after the ulcer was diagnosed, the median time to incriminate nicorandil was still 3·3 months, being shorter for mucosal ulcerations than for cutaneous ulcerations (5·2 versus 14·0 months, P = 0·001). The anatomic distribution in the 199 published cases differed slightly, but delays were similar. The hypothesis of mechanism becomes more precise, leaving no doubt about the necessity to discontinue the treatment. Practitioners need to be aware that nicorandil-induced ulcers can occur in many locations, possibly multiple and complicated, and should be simply managed by discontinuing treatment with no further reintroduction of nicorandil.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%