Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study
Abstract:Background:
Mass balance studies conducted using radiolabeled material (14C or 3H) definitively
characterize the Absorption, Metabolism, and Excretion (AME) of a drug. A critical aspect of
these studies is that the radiotracer maintains its proportion to total drug from its administration to its
complete elimination from the body. In the study of GDC-0276 in beagle dogs, we observed that the
14C radiotracer proportion (specific activity) varied through the study.
Method:
High resolution-accurate mass spectro… Show more
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