Uneven Linguistic Outcome in Extremely Preterm Children

Stefano, Paolucci; Marchignoli, M.; Pisani, Francesco; Cossu, Giuseppe

doi:10.1007/s10936-019-09662-x

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…Several studies suggested that language difficulties in preterm children are not a mere expression of cooccurring cognitive disabilities; instead, they seem to emerge as complications of prematurity that may selectively interfere with language acquisition [40].…”

Section: Discussionmentioning

confidence: 99%

Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort

Caporali

Longo²,

Tritto³

et al. 2022

Ital J Pediatr

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Background Preterm extremely low birth weight infants (ELBWi) are known to be at greater risk of developing neuropsychiatric diseases. Identifying early predictors of outcome is essential to refer patients for early intervention. Few studies have investigated neurodevelopmental outcomes in Italian ELBWi. This study aims to describe neurodevelopmental outcome at 24 months of corrected age in an eleven-year single-center cohort of Italian ELBWi and to identify early risk factors for adverse neurodevelopmental outcomes. Methods All infants born with birth weight < 1000 g and admitted to the Neonatal Intensive Care Unit of the “Fondazione IRCCS Policlinico San Matteo” hospital in Pavia, Italy, from Jan 1, 2005 to Dec 31, 2015 were eligible for inclusion. At 24 months, Griffiths’ Mental Developmental Scales Extended Revised (GMDS-ER) were administered. Neurodevelopmental outcome was classified as: normal, minor sequelae (minor neurological signs, General Quotient between 76 and 87), major sequelae (cerebral palsy; General Quotient ≤ 75; severe sensory impairment). Univariate and multivariate multinomial logistic regression models were performed to analyze the correlation between neonatal variables and neurodevelopmental outcome. Results 176 ELBWi were enrolled (mean gestational age 26.52 weeks sd2.23; mean birthweight 777.45 g sd142.89). 67% showed a normal outcome at 24 months, 17% minor sequelae and 16% major sequelae (4.6% cerebral palsy on overall sample). The most frequent major sequela was cognitive impairment (8.52%). In the entire sample the median score on the Hearing-Speech subscale was lower than the median scores recorded on the other subscales and showed a significantly weaker correlation to each of the other subscales of the GMDS-ER. Severely abnormal cUS findings (RRR 10.22 p 0.043) and bronchopulmonary dysplasia (RRR 4.36 p 0.008) were independent risk factors for major sequelae and bronchopulmonary dysplasia for minor sequelae (RRR 3.00 p 0.018) on multivariate multinomial logistic regression. Conclusions This study showed an improvement in ELBWI survival rate without neurodevelopmental impairment at 24 months compared to previously reported international cohorts. Cognitive impairment was the most frequent major sequela. Median scores on GMDS-ER showed a peculiar developmental profile characterized by a selective deficit in the language domain. Severely abnormal cUS findings and bronchopulmonary dysplasia were confirmed as independent risk factors for major sequelae.

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Section: Discussionmentioning

confidence: 99%

Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort

Caporali

Longo²,

Tritto³

et al. 2022

Ital J Pediatr

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“…The hearing and language subscale evaluates hearing, expressive and receptive language. Developmental language disorders are common in preterm children ( 31 ) and appear to be independent of the presence of significant abnormalities in brain morphology, IQ scores and neurological examination ( 32 ). In line with these findings, a recent Italian study ( 33 ) documented in a cohort of ELBW infants a peculiar developmental profile assessed through the GMDS-ER showing a selective deficit in the language domain.…”

Section: Discussionmentioning

confidence: 99%

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

Consales,

Porro,

Gangi

et al. 2023

Front. Pediatr.

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Background and ObjectivesVery low birth weight infants (VLBW) are at risk for adverse growth and neurodevelopmental outcomes. We aimed to evaluate the association between growth during Neonatal Intensive Care Unit (NICU) stay and long-term neurodevelopmental outcomes in a cohort of preterm VLBW newborns.MethodsWe conducted a longitudinal observational study in the Follow-up Service of our Clinic from January 2014 to April 2017. All preterm VLBW infants born at our hospital and enrolled in our follow-up program were considered eligible for the study. The neurodevelopmental assessment was performed using the Griffiths Mental Development Scales at 12 and 24 months corrected age.ResultsStudy population included 172 subjects (47.1% males) with a mean gestational age of 29 weeks and a mean birth weight of 1,117 g. A unitarian Δz-score increase in head circumference from birth to discharge was associated with a 1.6-point increase in General Quotient at 24 months corrected age. An association with subscales C and D was also found. Likewise, an increase in length Δz-score was associated with better 24-month subscale C scores although not reaching statistical significance. No relationship with the outcome at 24 months was found for weight gain.ConclusionsGrowth during NICU stay appears to be related to a more favorable neurodevelopmental outcome at 24 months corrected age, especially in the hearing and language domain (subscale C). The longitudinal evaluation of auxological parameters during hospitalization can contribute to the identification of subjects at risk for adverse neurodevelopmental outcomes in the first years of life.

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“…The development of school difficulties, especially that of reading and writing disorders, is usually associated with delayed language acquisition, and PIs often present with atypical language development, with higher incidence of delayed acquisition of expressive language. 49 …”

Section: Discussionmentioning

confidence: 99%

Neurological, cognitive and learning evaluation of students who were born preterm

Carmo

Fredo

Bruck

et al. 2022

Rev. paul. pediatr.

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Objective: To evaluate the cognitive and academic profile of preterm newborns at school age and to determine the factors related to prematurity and sociodemographic profile that influence these results. Methods: Patients aged 6-14 years old that were assisted in the preterm follow-up clinic were recruited. The cognitive, academic, and neurological capacities were accessed through a detailed evaluation with a child neurologist, a neuropsychologist and a psychopedagogue. Neonatal data were collected from patient records. Results: 97 children were included and 14 were excluded from the study, resulting in 83 children. Gestational age (GA) was 30±3 weeks and weight at birth was 1138g (605 to 4185g). Poor performance was shown in 38.4% for writing, 57.5% for reading and 42.5% for mathematics. The mean total intelligence quotient (IQ) was 96±14.9 points, and 10.9% were considered altered. Children with unstructured families presented 78.3% of failure in reading tests (p=0.029). The multivariate analysis showed association between GA at birth and classic mini-mental score (p=0.043), total IQ (p=0.047), perceptual organization IQ (p=0.035), and processing speed IQ (p=0.036). There was also association between weight at birth and the classic (p=0.004) and adapted (p=0.007) mini-mental scores; invasive mechanic ventilation duration and classic mini-mental (p=0.049); and lower maternal age and processing speed IQ (p=0.033). Conclusions: Preterm infants at school age had high frequency of failure in cognitive and academic evaluation tests. Learning difficulties are high among them. Multiple neonatal variables are related with altered cognitive and students development.

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Uneven Linguistic Outcome in Extremely Preterm Children

Cited by 3 publications

References 43 publications

Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort

Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

Neurological, cognitive and learning evaluation of students who were born preterm

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