Uneven terrain treadmill walking in younger and older adults

Downey, Ryan J.; Richer, Natalie; Gupta, Rohan; Liu, Chang; Pliner, Erika M.; Roy, Arkaprava; Hwang, Jungyun; Clark, David J.; Hass, Chris J.; Manini, Todd M.; Seidler, Rachael D.; Ferris, Daniel P.

doi:10.1101/2022.03.01.482507

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…The order of the trials was randomized. Details of the study design were reported in the previous papers [41], [43]. Participants completed two trials per condition, and each trial lasted for 3 minutes.…”

Section: B Experimental Protocolmentioning

confidence: 99%

Comparison of EEG source localization using simplified and anatomically accurate head models in younger and older adults

Liu¹,

Downey²,

Mu³

et al. 2023

Preprint

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<p>Accuracy of electroencephalography (EEG) source localization relies on the volume conduction head model. A previous analysis of young adults has shown that simplified head models have larger source localization errors when compared with head models based on magnetic resonance images (MRIs). As obtaining individual MRIs may not always be feasible, researchers often use generic head models based on template MRIs. It is unclear how much error would be introduced using template MRI head models in older adults that likely have differences in brain structure compared to young adults. The primary goal of this study was to determine the error caused by using simplified head models without individual-specific MRIs in both younger and older adults. We collected high-density EEG during uneven terrain walking and motor imagery for 15 younger (22±3 years) and 21 older adults (74±5 years) and obtained T1-weighted MRI for each individual. We performed equivalent dipole fitting after independent component analysis to obtain brain source locations using four forward modeling pipelines with increasing complexity. These pipelines included: 1) a generic head model with template electrode positions or 2) digitized electrode positions, 3) individual-specific head models with digitized electrode positions using simplified tissue segmentation, or 4) anatomically accurate segmentation. We found that when compared to the anatomically accurate individual-specific head models, performing dipole fitting with generic head models led to similar source localization discrepancies (up to 2 cm) for younger and older adults. Co-registering digitized electrode locations to the generic head models reduced source localization discrepancies by ~6 mm. Additionally, we found that source depths generally increased with skull conductivity for the representative young adult but not as much for the older adult. Our results can help inform a more accurate interpretation of brain areas in EEG studies when individual MRIs are unavailable. </p>

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Section: B Experimental Protocolmentioning

confidence: 99%

Comparison of EEG source localization using simplified and anatomically accurate head models in younger and older adults

Liu¹,

Downey²,

Mu³

et al. 2023

Preprint

View full text Add to dashboard Cite

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Mechanism-Driven Strategies for Reducing Fall Risk in the Elderly: A Multidisciplinary Review of Exercise Interventions

Zhong,

Meng,

2024

Healthcare

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Falls among older adults present a major public health challenge, causing significant physical, psychological, and economic consequences. Exercise interventions are a proven strategy to reduce fall risk by targeting biomechanical, physiological, and psychological factors. This review examines evidence from 155 studies published between 2004 and 2024, including systematic reviews, meta-analyses, randomized controlled trials, and cohort studies. Data were rigorously screened and extracted using predefined criteria, with studies sourced from PubMed, MEDLINE, EBSCO (EDS), and additional gray literature identified via Google Scholar. Key findings show that balance and strength training improves postural control, gait stability, and neuromuscular coordination, while resistance training mitigates sarcopenia and enhances joint mobility. Cognitive exercises enhance attention, spatial awareness, decision-making, and psychological benefits like reduced fear of falling and greater social engagement. Multidisciplinary approaches integrating physical, cognitive, and social components deliver the most significant impact. This review underscores the value of evidence-based exercise programs in promoting active aging and enhancing the quality of life for older adults.

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iCanClean Improves Independent Component Analysis of Mobile Brain Imaging with EEG

Gonsisko

Ferris

Downey

2023

Sensors

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Motion artifacts hinder source-level analysis of mobile electroencephalography (EEG) data using independent component analysis (ICA). iCanClean is a novel cleaning algorithm that uses reference noise recordings to remove noisy EEG subspaces, but it has not been formally tested in a parameter sweep. The goal of this study was to test iCanClean’s ability to improve the ICA decomposition of EEG data corrupted by walking motion artifacts. Our primary objective was to determine optimal settings and performance in a parameter sweep (varying the window length and r2 cleaning aggressiveness). High-density EEG was recorded with 120 + 120 (dual-layer) EEG electrodes in young adults, high-functioning older adults, and low-functioning older adults. EEG data were decomposed by ICA after basic preprocessing and iCanClean. Components well-localized as dipoles (residual variance < 15%) and with high brain probability (ICLabel > 50%) were marked as ‘good’. We determined iCanClean’s optimal window length and cleaning aggressiveness to be 4-s and r2 = 0.65 for our data. At these settings, iCanClean improved the average number of good components from 8.4 to 13.2 (+57%). Good performance could be maintained with reduced sets of noise channels (12.7, 12.2, and 12.0 good components for 64, 32, and 16 noise channels, respectively). Overall, iCanClean shows promise as an effective method to clean mobile EEG data.

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Uneven terrain treadmill walking in younger and older adults

Cited by 3 publications

References 49 publications

Comparison of EEG source localization using simplified and anatomically accurate head models in younger and older adults

Comparison of EEG source localization using simplified and anatomically accurate head models in younger and older adults

Mechanism-Driven Strategies for Reducing Fall Risk in the Elderly: A Multidisciplinary Review of Exercise Interventions

iCanClean Improves Independent Component Analysis of Mobile Brain Imaging with EEG

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