Unexpected associations of long-term and excessive exposure to trivalent chromium with hypertension and glycosuria in male tannery workers

Tsuchiyama, Tomoyuki; Chen, Dijie; Hossain, M.M. Aeorangajeb Al; Kagawa, Takumi; Gu, Yishuo; Gao, Yanlin; Kurniasari, Fitri; Ahsan, Nazmul; Akhand, Anwarul A.; Kato, Masaya

doi:10.1016/j.chemosphere.2023.139190

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…This study categorized human participants with a wide range of fasting serum arsenic levels according to the cut-off value of 1.7 µg/L determined based on the maximum Youden index for predicting the prevalence of hypertension in receiver operating characteristic (ROC) curve analysis. 46 To investigate the dose–response relationship between arsenic levels in fasting serum and the prevalence of hypertension, a restricted cubic spline regression model was used following a previous study. 47 The concentrations of serum arsenic below the lower limit of detection (LOD) were provided as the value of the LOD divided by the square root of two, as previously described.…”

Section: Methodsmentioning

confidence: 99%

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice

Kagawa,

Ohgami,

et al. 2023

European Heart Journal Open

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Aims There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies. Methods and results This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice. Conclusion This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.

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Section: Methodsmentioning

confidence: 99%