Unexpected Behavior of 5‐Phenoxypyrazole Derivatives.

Park, Hyun‐Ja; Lee, Jong‐Cheol; Kim, Yeong‐Joon; Lee, Kee‐In

doi:10.1002/chin.200537117

ChemInform

2005

DOI: 10.1002/chin.200537117

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Unexpected Behavior of 5‐Phenoxypyrazole Derivatives.

Hyun‐Ja Park¹,

Jong‐Cheol Lee²,

Yeong‐Joon Kim³

et al.

Abstract: For Abstract see ChemInform Abstract in Full Text.

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“…The pyrazole-based derivatives have shown several biological activities, many of them are currently being tested and/or clinically evaluated for new drug discovery 1 . Various pyrazole and pyrazoline derivatives have been reported to possess antinociceptive effect in mice 2 , antimicrobial 3 4 , insecticidal 5 and local anesthetic 6 activities.…”

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confidence: 99%

Synthesis and activity evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles

Kumaraswamy

Chikkanna

Shivakumar³

et al. 2008

Indian J Pharm Sci

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Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in presence of acetic acid as catalyst in dioxane produces 1-(naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles (7a-o). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. The compounds 7a-o have been evaluated for their antimicrobial activity and some selected compounds evaluated for antiinflammatory, analgesic, anthelmintic, diuretic and antipyretic activities.

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mentioning

confidence: 99%

Synthesis and activity evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles

Kumaraswamy

Chikkanna

Shivakumar³

et al. 2008

Indian J Pharm Sci

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Unexpected Behavior of 5‐Phenoxypyrazole Derivatives.

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 1 publication

References 1 publication

Synthesis and activity evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles

Synthesis and activity evaluation of 2-(1-naphtho[2,1-b]furan-2-yl-carbonyl)-3,5-disubstituted-2,3-dihydro-1H-pyrazoles

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