Unexpected formation of hydroxybiphenylmethane derivatives and some new observations on Labat test

Abstract

An unexpected synthesis of symmetrical hydroxybiphenylmethanes involving the reaction of 2-hydroxyphenyl benzyl ketones with ethoxymethyl chloride has been observed. Some new interesting observations of Labat test on colorimetric detection of bichalconyloxy, bichalconyl and biflavonylmethanes having oxygenated ortho positions are presented.

Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance

“…CYP3A5 is expressed in most Africans but in few Caucasians and Asians. The wild‐type, functional CYP3A5*1 allele is present in 14% of Swedes, 33% of Koreans, and 74% of Tanzanians 7 , 8 , 9 . The expression of CYP3A enzymes is regulated by nuclear receptors, including the pregnane X receptor (NR1I2), the vitamin D receptor, and retinoid X receptor α, and different levels of regulation can cause high interindividual variation in CYP3A activity 10 , 11 , 12 .…”