Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?

Zhang, Pingyu; Wang, Jinquan; Huang, Huaiyi; Yu, Baoxian; Qiu, Kangqiang; Huang, Juanjuan; Wang, Shutao; Jiang, Lei; Gasser, Gilles; Ji, Liang‐Nian; Chao, Hui

doi:10.1016/j.biomaterials.2015.06.012

Cited by 63 publications

(39 citation statements)

References 66 publications

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“…25A). 286 The Ru@AuNPs converted NIR (808 nm) light to heat (ΔT = 9.4–38.5 °C), with high photothermal therapy efficiency (ΔT = 38.5 °C, η = 33.3%), which was well over the required temperature increase for efficient cancer photothermal therapy. More importantly, the in vivo experiments indicated that Ru@AuNPs , as PTT compounds, had significant tumor ablation efficacy.…”

Section: Ruthenium(ii)-based Nanomaterials Systemsmentioning

confidence: 95%

“…Indeed, under diode laser (808 nm) irradiation at the power density of 0.8 W/cm 2 for 5 min, tumors shrunk gradually or disappeared individually after 10 days of treatments. 286 This study with Ru(II) complex modifications provides an effective solution for overcoming the typically poor NIR absorbance and low photostability (melting effect) of gold nanoparticles in PTT. Recently, the same group developed two novel gold nanostructures to get the Ru(II)-functionalized gold nanorods, ( AuNRs@Ru ) and nanostars ( AuNTs@Ru ) (see Fig.…”

Section: Ruthenium(ii)-based Nanomaterials Systemsmentioning

confidence: 98%

Section: Figmentioning

confidence: 99%

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The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

et al. 2017

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Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer drugs are organic molecules, while metallodrugs are very scarce. The advent of first metal based therapeutic agent, cisplatin, launched a new era in the application of transition metal complexes for therapeutic design. Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anti-cancer agents that serve as alternatives to cisplatin and its derivertives. The ruthenium(III) complexes have successfully been used in clinical research and their mechanisms of anticancer action have been reported in large volumes over the past few decades. Ruthenium(II) complexes have also attracted significant attention as anticancer candidates; however, only few of them have been reported comprehensively. In this review, we discuss the development of ruthenium(II) complexes as anticancer candidates and biocatalysts, including arene ruthenium complexes, polypyridyl ruthenium complexes, and ruthenium nanomaterial complexes. This review focuses on the likely mechanisms of action of ruthenium(II)-based anticancer drugs and the relationship between their chemical structures and biological properties. This review also highlights the catalytic activity and the photoinduced activation of ruthenium(II) complexes, their targeted delivery, and their activity in nanomaterial systems.

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Section: Ruthenium(ii)-based Nanomaterials Systemsmentioning

confidence: 95%

Section: Ruthenium(ii)-based Nanomaterials Systemsmentioning

confidence: 98%

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The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

et al. 2017

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“…The employment of near-infrared (NIR) radiations in photothermal therapy (PTT) to treat cancer is current high pitched interest aside from its classical applications such as telecommunication, sensing ablation etc [1,2]. The reason is that NIR region (700–1100 nm) is ideal clinical phototherapeutic window for PTT as attenuation of NIR radiations by skin, blood and tissues is low and it allow for the treatment of deep-seated tumors.…”

Section: Introductionmentioning

confidence: 99%

Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite

Neelgund

Oki

2016

Journal of Colloid and Interface Science

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Herein we present a successful strategy for efficient enhancement of photothermal efficiency of hydroxyapatite (HAP) by its conjugation with carbon nanotubes (CNTs) and graphene nanosheets (GR). Owing to excellent biocompatibility with human body and its non-toxicity, implementation of HAP based nanomaterials in photothermal therapy (PTT) provides non-replaceable benefits over currently using PTE agents. Therefore, in this report, it has been experimentally exploited that the photothermal effect (PTE) of HAP has significantly improved by its assembly with CNTs and GR. It is found that the type of carbon nanomaterial used to conjugate with HAP has influenced on its PTE in such a way that the photothermal efficiency of GR-HAP was higher than CNTs-COOH-HAP under exposure to 980 nm near-infrared (NIR) laser. The temperature attained by aqueous dispersions of both CNTs-COOH-HAP and GR-HAP after illuminating to NIR radiations for 7 min was found to be above 50 ° C, which is beyond the temperature tolerance of cancer cells. So that the rise in temperature shown by both CNTs-COOH-HAP and GR-HAP is enough to induce the death of tumoral or cancerous cells. Overall, this approach in modality of HAP with CNTs and GR provide a great potential for development of future nontoxic PTE agents.

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“…Researchers have been attempting to find a perfect match to gold and ligand complexes with fewer side effects [33][34][35][36][37][38][39]. Antitumor activities of new gold(III) complexes with 1,2-diaminocyclohexane were estimated in prostate cancer and gastric carcinoma by Al-Jaroudi et al [40].…”

Section: Discussionmentioning

confidence: 99%

Gold(III) compounds-mediated inhibition of lung cancer cell proliferation

Bostancıoğlu

Kaya²,

Koparal³

et al. 2016

Anti-Cancer Drugs

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Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert toxic effects on healthy cells, have a limited advantage, they are the primary treatment modalities for non-small lung cancer. In addition to cytotoxicity, resistance of chemotherapeutics results in failure of treatment. This is why it is of utmost importance to focus on the creation of new chemotherapeutics without toxicity for the successful treatment and improved survival of cancer patients. New gold(III) and Pt(II) compounds were synthesized with a heterocyclic ligand using 2-phenylimidazo[4,5-f][1,10]phenanthroline as a ligand and bis-1,4-di[([1,10] phenanthroline-5-il)amino]-2-buten as a bridge molecule. The characterization of the compounds was carried out using a variety of spectroscopic methods (H NMR, IR, MS, and elemental analysis). Their antiproliferative, antitumoral, and apoptotic activities were determined. IR spectra and NMR results confirmed the formation of dinuclear heterocyclic complexes for two metal complexes. Cytotoxicity studies on lung cancer cells (A549) and healthy cells (CHL) showed a marked increase in cytotoxicity with the use of gold(III) complexes, and especially [Au(L)B](PF6)2 showed higher cytotoxic and apoptotic features than cisplatin at lower concentrations in cancer cells. These findings have been supported by results from DAPI staining and colorimetric measurement of the caspase-3 enzyme in both cell lines. Compounds showed selective toxicity on the cancer cells. In the light of the high efficacy of our newly synthesized gold complexes, they might be good and promising anticancer agents compared with cisplatin.

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Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?

Cited by 63 publications

References 66 publications

The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite

Gold(III) compounds-mediated inhibition of lung cancer cell proliferation

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