2014
DOI: 10.1016/j.meegid.2014.10.014
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Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases

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Cited by 22 publications
(21 citation statements)
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“…However, it is important to take into account that a direct association between the human ancestry and HPV lineage is not necessarily expected in a population with ethnic admixture and with individuals having different proportions of genetic ancestry. This fact was reported by Lopera et al [] analyzing women with cervical cancer that presented an inverse correlation between infections by HPV16 lineage D (common in Native American population) with the higher proportion of informative genetic markers (AIMs) from Native American ancestry. To better understand this finding it is required to analyze the prevalence of these lineages in women without cancer, because the current prevalence in invasive cancer might be associated with differences of their carcinogenic potential in the studied population.…”
Section: Discussionmentioning
confidence: 58%
See 1 more Smart Citation
“…However, it is important to take into account that a direct association between the human ancestry and HPV lineage is not necessarily expected in a population with ethnic admixture and with individuals having different proportions of genetic ancestry. This fact was reported by Lopera et al [] analyzing women with cervical cancer that presented an inverse correlation between infections by HPV16 lineage D (common in Native American population) with the higher proportion of informative genetic markers (AIMs) from Native American ancestry. To better understand this finding it is required to analyze the prevalence of these lineages in women without cancer, because the current prevalence in invasive cancer might be associated with differences of their carcinogenic potential in the studied population.…”
Section: Discussionmentioning
confidence: 58%
“…Few Brazilian studies have studied HPV16 and HPV18 intra‐type variants [Villa et al, ; Cruz et al, ; Sichero et al, ; Cerqueira et al, ; Junes‐Gill et al, ; Sichero et al, ; Freitas et al, ], and almost no studies have investigated samples obtained from invasive cancer [Junes‐Gill et al, ]. Interest in HPV16 and HPV18 intra‐type diversity has been increasing in recent years due to reports suggesting an interaction between host and viral characteristics influencing the natural history of infection and the prognosis of lesions at different stages [de Araujo Souza et al, , ; Lopera et al, ].…”
Section: Introductionmentioning
confidence: 99%
“…Possible mechanisms related to the immune response enable better elimination of infection by certain variants in specific populations [25, 26]. Evidence has been presented that genetic differences between racial groups might explain the functional diversity of immune response factors, inflammation, metabolism, etc., in response to HPV infection [27].…”
Section: Discussionmentioning
confidence: 99%
“…Samples analyzed in this study stem from a formalin-fixed paraffin-embedded (FFPE) sample repository from the Catalan Institute of Oncology (ICO), Barcelona, Spain, designed and constructed for the assessment of HPVs contribution to a number of anogenital human tumors [4,6,[8][9][10]. All samples were tested for the presence of tumor tissue and for the presence of HPVs DNA using the SPF 10 -LiPA 25 protocol, capable of genotyping HPV6, 11,16,18,31,33,34,35,39,40,42,43,44,45,51,52,53,54,56,58,59,66,68,70, and 74 (version 1; Laboratory Biomedical Products, Rijswijk, the Netherlands). For this study, we selected 711 invasive squamous cell carcinomas showing exclusively the presence of HPV16 DNA after LiPA 25 genotyping.…”
Section: Samplesmentioning
confidence: 99%