Unexpected one pot C (aryl)–N bond cleavage and Questiomycin A formation from the reduction reaction of 2-amino-6-nitrophenol derivatives

Mustafa, Shaik; Reddy, K. Santhosh; Babu, M.

doi:10.1016/j.tetlet.2015.09.080

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…It has been subsequently reused for a representative continuous flow transformation of 100 mmol reaching a productivity of 0.6 g h –1 in the preparation of Questiomycin A and derivatives. The E-factor values have been calculated for the flow protocol (E-factor = 1.12) and compared with other known procedures previously utilized to prepare the same compounds (E-factor range = 68–368). , In addition, the total mass recovery parameter (MRP), solvent recovery parameter (SRP), and reaction mass efficiency (RME) have been calculated and compared with the batch procedure using radial polygons, ultimately helping to assess a very good sustainability profile. In this example, the E-factors that mainly affected the improvements in terms of sustainability are (i) use of a heterogeneous recoverable and reusable Mn-based catalyst which allowed a very simple workup, (ii) adoption of flow conditions which increased the productivity, and (iii) solvent recovery and reuse effectively optimized thanks to the flow approach and reduced final associated E-factor values.…”

Section: Green Chemistry Metrics and Application In Flow Synthesismentioning

confidence: 99%

Quantitative Sustainability Assessment of Flow Chemistry–From Simple Metrics to Holistic Assessment

Hessel

Escribà‐Gelonch

Bricout

et al. 2021

ACS Sustainable Chem. Eng.

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Flow chemistry has changed chemical process designs toward process intensification and is generally considered as green methodology. In this connection, this perspective provides a more critical and holistic view about the sustainability of flow chemistry by introducing both simple and complex holistic tools for environmental quantitative assessment on sustainability and providing examples of how they were used for flow chemistry. The latter also shows a critical assessment of what flow chemistry can add to make chemical processes more sustainable. With the increasing complexity of assessment, green chemistry metrics, life cycle assessment methodology, and circular transition indicators are discussed. In this way, the sustainability of flow chemistry is assessed first on the level of a reaction only and then moving to a process level and beyond. Flow chemists are very aware of the principles of green chemistry and their simple metrics. Yet, they hardly use life cycle assessment, and quantitative circularity analysis has not been made. When those assessments are used, it is usually done by researchers with an ecology background. This perspective aims to make flow chemists aware of the opportunities that complex environmental assessment can provide and that protecting our planet requires a holistic sustainability consideration. The perspective critically states what each of the three types of assessments can do and what their limitations are.

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Section: Green Chemistry Metrics and Application In Flow Synthesismentioning

confidence: 99%

Quantitative Sustainability Assessment of Flow Chemistry–From Simple Metrics to Holistic Assessment

Hessel

Escribà‐Gelonch

Bricout

et al. 2021

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

Unexpected one pot C (aryl)–N bond cleavage and Questiomycin A formation from the reduction reaction of 2-amino-6-nitrophenol derivatives

Cited by 1 publication

References 22 publications

Quantitative Sustainability Assessment of Flow Chemistry–From Simple Metrics to Holistic Assessment

Quantitative Sustainability Assessment of Flow Chemistry–From Simple Metrics to Holistic Assessment

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