A region often neglected in the grander scale of general atmospheric chemistry studies and model evaluation for gasphase chemistry is the desert southwest of the U.S. Despite regulatory progress, challenges in meeting the National Ambient Air Quality Standard for ozone motivate a re-examination of the unique meteorological conditions, interactions between the desert, agricultural, and built environmental landscapes, emissions across natural and anthropogenic sources, and regional transport of precursors that govern ozone formation in the desert Southwest. Arizona includes multiple nonattainment counties with a unique situation in terms of its environment (e.g., vegetation, meteorology, fire prone areas), complex terrain, urban growth, transport vulnerability, and limited knowledge base. Here we summarize past works investigating the ozone over Arizona, including 61 peerreviewed publications found since the first one in 1996, and determine significant knowledge gaps to guide future research with the aim of improving regulatory policy. A more in-depth focus is placed here on Maricopa County, which includes the Phoenix Metropolitan area, where significant population growth in recent decades coupled with the extreme high temperatures and surrounding complex terrain creates a poorly understood airshed in terms of ozone chemistry, thereby complicating regulatory decisions. We suggest paths forward, including improved monitoring, assessment, and modeling tools for the region, better leveraging of archived data, and engagement with the public, government, and policy. This Review is highly relevant as well to other semiarid and arid regions, which represent the most common land type globally, warranting more attention.