Unexpected resilience to experimental gingivitis of subepithelial connective tissue grafts in gingival recession defects: a clinical–molecular evaluation

Abstract

Analysis of the data demonstrates that the sites of gingival recession treated with SCTG develop a lower degree of plaque-induced inflammation compared to healthy gingivae. This strongly suggests that SCTG does not predispose to inflammation and to further gingival recession and makes it a safe technique in the treatment of gingival defects.

Resident memory T cells: Possible players in periodontal disease recurrence

“…32 In the present study, we did not discriminate between CD4 A recent study reported a milder inflammatory response in terms of gingival crevicular levels of interleukin-α in gingival recession sites after bilaminar root coverage procedures when compared to control sites treated by plaque control alone. 38 An important limitation of the present study is the difficulty in characterizing CD69+ and CD103+ cells to fully demonstrate their T cell phenotype. Based on morphological assessment ( Figure S1), these cells resemble mature lymphocytes and do not show features of other inflammatory cells, which can potentially express CD69 or CD103 (eg, neutrophils, eosinophils, and macrophages); considered that B cells do not usually localize within epithelial layers, the observed CD69+ and CD103+ cells were most likely T lymphocytes.…”

“…A previous study demonstrated that the dimension of inflammatory infiltrate was lower in areas treated by gingivectomy than in sextants treated by open flap debridement . A recent study reported a milder inflammatory response in terms of gingival crevicular levels of interleukin‐α in gingival recession sites after bilaminar root coverage procedures when compared to control sites treated by plaque control alone …”