Unexpectedly resisting protein adsorption on self-assembled monolayers terminated with two hydrophilic hydroxyl groups

Mao, Dangxin; Wu, Yi; Tu, Yusong

doi:10.1039/d3cp02376a

Cited by 3 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These issues are necessary to explore for the rational design and precise customization of anti-fouling surfaces. Our recent study [16] has also proposed a new mechanism of resistance to protein adsorption, namely, the structure of SAM itself.…”

Section: Introductionmentioning

confidence: 99%

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Mao 毛,

Wu 吴,

Tu 涂

2024

Chinese Phys. B

View full text Add to dashboard Cite

The hydroxyl-terminated self-assembled monolayer (OH-SAM), as a surface resistant to protein adsorption, exhibits substantial potential in applications such as ship navigation and medical implants, and the appropriate strategies for designing anti-fouling surfaces are crucial. Here, we employ molecular dynamics simulations and alchemical free energy calculations to systematically analyze the factors influencing resistance to protein adsorption on the SAMs terminated with single or double OH groups at three packing densities (Σ=2.0 nm-2, 4.5 nm-2, and 6.5 nm-2), respectively. For the first time, we observe that the compactness and order of interfacial water enhance its physical barrier effect, subsequently enhancing the resistance of SAM to protein adsorption. Notably, the spatial hindrance effect of SAM leads to the embedding of protein into SAM, resulting in a lack of resistance of SAM towards protein. Furthermore, the number of hydroxyl groups per unit area of double OH-terminated SAM at Σ=6.5 nm-2 is approximately 2 to 3 times that of single OH-terminated SAM at Σ=6.5 nm-2 and 4.5 nm-2, consequently yielding a weaker resistance of double OH-terminated SAM towards protein. Meanwhile, due to the structure of SAM itself, i.e., the formation of a nearly perfect ice-like hydrogen bond structure, the SAM exhibits the weakest resistance towards protein. This study will complement and improve the mechanism of OH-SAM resistance to protein adsorption, especially the traditional barrier effect of interfacial water.

show abstract

Section: Introductionmentioning

confidence: 99%

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Mao 毛,

Wu 吴,

Tu 涂

2024

Chinese Phys. B

View full text Add to dashboard Cite

show abstract

Linker-induced hollow MOF embedded into arginine-modified montmorillonite for efficient urea removal: Adsorption behavior and mechanism analysis

Sun,

Zha,

et al. 2025

Separation and Purification Technology

View full text Add to dashboard Cite

Pressure-induced magnetic phase and structural transition in SmSb₂

Li 李,

Wang 王,

Chen 陈

et al. 2024

Chinese Phys. B

View full text Add to dashboard Cite

Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb2, here we present a high-pressure study of an isostructural antiferromagnetic (AFM) SmSb2 through electrical transport and synchrotron x-ray diffraction measurements. At P C ~2.5 GPa, we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition. In the pristine AFM phase below P C, the AFM transition temperature of SmSb2 is insensitive to pressure; in the emergent magnetic phase above P C, however, the magnetic critical temperature increases rapidly with increasing pressure. In addition, at ambient pressure, the magnetoresistivity (MR) of SmSb2 increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K. With increasing pressure above P C, the MR behavior remains similar to that observed at ambient pressure, both in terms of temperature- and field-dependent MR. This leads us to argue an AFM-like state for SmSb2 above P C. Within the investigated pressure of up to 45.3 GPa and the temperature of down to1.8 K, we found no signature of superconductivity in SmSb2.

show abstract

Unexpectedly resisting protein adsorption on self-assembled monolayers terminated with two hydrophilic hydroxyl groups

Abstract: The OH-terminated self-assembled monolayers, as protein-resistant surfaces, have significant potential in biocompatible implant devices, which can avoid or reduce adverse reactions caused by protein adhesion to biomaterial surfaces, such as...

Cited by 3 publications

References 42 publications

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Linker-induced hollow MOF embedded into arginine-modified montmorillonite for efficient urea removal: Adsorption behavior and mechanism analysis

Pressure-induced magnetic phase and structural transition in SmSb₂

Contact Info

Product

Resources

About

Unexpectedly resisting protein adsorption on self-assembled monolayers terminated with two hydrophilic hydroxyl groups

Abstract: The OH-terminated self-assembled monolayers, as protein-resistant surfaces, have significant potential in biocompatible implant devices, which can avoid or reduce adverse reactions caused by protein adhesion to biomaterial surfaces, such as...

Cited by 3 publications

References 42 publications

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Factors resisting protein adsorption on hydrophilic/hydrophobic self-assembled monolayers terminated with hydrophilic hydroxyl groups

Linker-induced hollow MOF embedded into arginine-modified montmorillonite for efficient urea removal: Adsorption behavior and mechanism analysis

Pressure-induced magnetic phase and structural transition in SmSb2

Contact Info

Product

Resources

About

Pressure-induced magnetic phase and structural transition in SmSb₂