Unfavorable effects of memantine on the skeletal system in female rats

Londzin, Piotr; Cegieła, Urszula; Trawczyński, Marcin; Czuba, Zenon; Folwarczna, Joanna

doi:10.1016/j.biopha.2023.114921

Cited by 2 publications

(1 citation statement)

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“…Noteworthy is a study indicating a higher likelihood of early-onset AD in males treated with memantine, whereas females were more linked to late-onset AD ( Miller et al, 2022 ), which this divergence in association could possibly stem from sex-related differences in the effectiveness of memantine treatment. However, understanding the precise mechanism requires further investigation and worth noting is memantine’s potential slightly negative impact on female rat skeletal health relative to males ( Londzin et al, 2023 ). Interestingly, during the prodromal stages of AD, treatment with rivastigmine has been observed to delay the progression from MCI to AD in women, but not in men.…”

Section: Sex Differences In Alzheimer’s Diseasementioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Depression and Alzheimer’s disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive disorders significantly contribute to AD risk, and approximately a quarter of AD patients have comorbid major depressive disorder, which underscores the bidirectional link between AD and depression. A growing body of evidence substantiates pervasive sex differences in both AD and depression: both conditions exhibit a higher incidence among women than among men. However, the available literature on this topic is somewhat fragmented, with no comprehensive review that delineates sex disparities in the depression–AD correlation. In this review, we bridge these gaps by summarizing recent progress in understanding sex-based differences in mechanisms, genetics, and therapeutic prospects for depression and AD. Additionally, we outline key challenges in the field, holding potential for improving treatment precision and efficacy tailored to male and female patients’ distinct needs.

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Section: Sex Differences In Alzheimer’s Diseasementioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Effects of Donepezil on the Musculoskeletal System in Female Rats

Londzin

Trawczyński

Cegieła

et al. 2023

IJMS

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The extension of human life makes it more and more important to prevent and treat diseases of the elderly, including Alzheimer’s disease (AD) and osteoporosis. Little is known about the effects of drugs used in the treatment of AD on the musculoskeletal system. The aim of the present study was to investigate the effects of donepezil, an acetylcholinesterase inhibitor, on the musculoskeletal system in rats with normal and reduced estrogen levels. The study was carried out on four groups of mature female rats: non-ovariectomized (NOVX) control rats, NOVX rats treated with donepezil, ovariectomized (OVX) control rats and OVX rats treated with donepezil. Donepezil (1 mg/kg p.o.) was administered for four weeks, starting one week after the ovariectomy. The serum concentrations of CTX-I, osteocalcin and other biochemical parameters, bone mass, density, mineralization, histomorphometric parameters and mechanical properties, and skeletal muscle mass and strength were examined. Estrogen deficiency increased bone resorption and formation and worsened cancellous bone mechanical properties and histomorphometric parameters. In NOVX rats, donepezil decreased bone volume to tissue volume ratio in the distal femoral metaphysis, increased the serum phosphorus concentration and tended to decrease skeletal muscle strength. No significant bone effects of donepezil were observed in OVX rats. The results of the present study indicate slightly unfavorable effects of donepezil on the musculoskeletal system in rats with normal estrogen levels.

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Unfavorable effects of memantine on the skeletal system in female rats

Cited by 2 publications

References 80 publications

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Effects of Donepezil on the Musculoskeletal System in Female Rats

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