Ungew�hnliche histologische Ver�nderungen bei Reticulosarkomatosen unter dem klinischen Bilde der Mycosis fungoides (Einlagerung doppeltbrechender Lipoide, Umwandlung des Infiltrates in Plasmazellen, Arteriitiden)

Steigleder, G. K.; Lauckner, Hans Georg

doi:10.1007/bf00477277

Cited by 5 publications

(1 citation statement)

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“…50). These may be T-or 8-lymphocytes (51). Pathological B-lymphocytes produce patholog-ical immune globulin� which arc not infrequently to be foun<l in patients with lymphomas (21.…”

Section: Il \1alig11a11t Pro/iferatil'e Respo111ementioning

confidence: 99%

Benign and malignant proliferative response. Dermal infiltration, origin and importance

Steigleder¹

1975

Acta Derm Venereol

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Lymphoreticular infiltration (LRI) is the most common type of dermal infiltration. The LRI is made up of two main components: (i) a dermal skeleton, and (ii) the infiltration in a strict sense. (i) The dermal skeleton consists of the blood vessel involved, most probably a post-capillary venule, and activated fibroblasts (Fig. 3). The activated fibroblasts contain "paraplasmatic granules" in their processes (Fig. 4). Since the fibroblasts are in mutual contact by their ramifications (Fig. 3), they are reticulum cells by definition (Bessis). In our opinion they are the only local reticulum cells in the dermis. They are not stem cells, nor do they belong to the reticulo-endothelial system and they do not give rise to histiocytes. (ii) In the skeleton of LRI, other cells infiltrate, predominantly monocytes and lymphocytes. The LRI may specialize and contain various amounts of neutrophilic, basophilic, or eosinophilic leukocytes and plasma cells. If enough B-lymphocytes and plasmacells are involved, abnormal globulins may be produced (e.g. syphilis II). The lymphomas are considered to be malignant proliferative disorders of LRI-type. LRI is found in allergic spreading reactions mediated by stimulated lymphocytes. A similar spreading of lymphocytes is to be expected if the allergen sensitizes a lymphocyte with neoplastic information (e.g. tumor virus) (Fig. 6). The degree of dedifferentiation and the response of the organism to the dedifferentiated lymphocytes is the reason for the variety of lymphomas.

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“…50). These may be T-or 8-lymphocytes (51). Pathological B-lymphocytes produce patholog-ical immune globulin� which arc not infrequently to be foun<l in patients with lymphomas (21.…”

Section: Il \1alig11a11t Pro/iferatil'e Respo111ementioning

confidence: 99%