Unicentric Castleman’s Disease: Case Report and Literature Review

Abstract

Castleman's disease (CD), also known as giant lymph node hyperplasia or angiofollicular lymph node dysplasia, is a rare benign immunoproliferative disorder. CD is classified by histopathologic appearance (hyaline vascular, plasma cell or mix variant) as well as by the number of lymph nodes that are involved (unicentric and multicentric). We report the case of a 24-year-old female who was found to have unicentric anterior mediastinum CD. This article describes the clinical features, pathogenesis, diagnosis, and current treatment modalities for this uncommon disease.

Enfermedad de castleman unicéntrica: revisión breve de una enfermedad poco conocida

“…La causa de la ECU no ha sido dilucidada, a diferencia de la de la ECM cuyos factores etiológicos han sido analizados en varios estudios, identificando su asociación con factores predisponentes como la infección por el virus herpes humano tipo 8 (VHH8) y el virus de la inmunodeficiencia humana (VIH) (8,11,12). Esta relación no ha sido observada con la ECU (1,3).…”