Anthropogenic modifications are changes in the landscape resulting from interventions on natural elements, usually related to the types of land use and coverage. This article analyzes the main biophysical components of the estuarine municipalities of the Sado River - emphasizing geology, geomorphology and anthropogenic derivations of the landscape. The systemic principles are the theoretical-methodological support of this integrated analysis. Cartographic materials, remote sensing techniques, Geographic Information Systems (GIS) and fieldwork were used. The components most impacted by anthropogenic interventions are: hydrography - with dams in river channels, which alter the flow dynamics and hydrosedimentary processes, favoring the occurrence of erosion in the tidal plain and siltation in the estuary, which requires dredging to maintain activity in the port of Setúbal; vegetation, soils, geology and geomorphology - with mining, which directly implies the suppression of vegetation and soils, the dismantling of relief and rocks, reduces biodiversity, characterizes the landscape, and is a potential risk of soil and water contamination. In the tidal plain originally colonized by salt marshes, there are significant economic activities: rice farming, salt culture, aquaculture and industrial area. Touristic developments are installed on the recent features of the coastal plain of the Tróia peninsula. These anthropogenic derivations affect the systemic relationships of natural elements and cause changes in the landscape. This integrated analysis can contribute to better planning and management of activities with environmental and social sustainability for the municipalities in the study area.