Unified approach for synthesizing crystallization‐based separation processes

Solubility of Diamantane, Trimantane, Tetramantane, and Their Derivatives in Organic Solvents

“…1/2 (6) where N is the number of experimental data points and x i,exptl and x i,c refer to the experimental solubility and solubility calculated from eq 5, respectively. The results show that the empirical equation can be used to correlate satisfactorily the solubility of trimantane, tetramantane, 1-hydroxyl diamantane, and 1,6-dihydroxyl diamantane.…”

Visualization of high‐dimensional phase diagrams of molecular and ionic mixtures

“…Figure 3b is the front triangular face, which represents the phase diagram of a three-solute system with compound formation. With a phase diagram on hand, we can synthesize a process for separating (R)AH and ( S ) A H as their potassium salts, using techniques available in the literature (Berry and Ng, 1996;Wibowo and Ng, 2000;Schroer et al, 2001). The flowsheet is depicted in Figure 4, and the process path is drawn on various cuts depicted in Figure 5.…”

“…Visualization of phase equilibrium data in the form of phase diagrams is very useful in process design and synthesis. Synthesis procedures based on phase diagrams are available for distillation processes (Biegler e t al., 1997), crystallization-based separations (Wibowo and Ng, 2000), extractive reaction processes (Samant and Ng, 19981, and hybrid systems (Berry and Ng, 1997;Pressly and Ng, 1999). However, all of these studies focused on systems with twoand three-dimensional (3-D) phase diagrams.…”

Separation and purification of (−)schisandrin B from schisandrin B stereoisomers

“…For a particular system, the flowsheet of a crystallization-based separation process can be synthesized based on knowledge of solid-liquid equilibrium (SLE) phase behavior. The key idea is to identify the crystallization compartment/region of the desired component on the SLE phase diagram, and to navigate the feed composition of crystallizers to reach the appropriate region by a sequence of operations, such as cooling, heating, solvent addition or solvent removal [5][6][7]. Therefore, the SLE phase behavior of the ternary system comprising (±)␥-schisandrin, (−)Sch B and ethanol (the selected solvent) is firstly determined.…”