This paper presents a novel decision-making framework for the life cycle management of aircraft components, integrating advanced data analytics, artificial intelligence, and predictive maintenance strategies. The proposed model addresses the challenges of balancing safety, reliability, and cost-effectiveness in aircraft maintenance. By using real-time health monitoring systems, failure probability models, and economic analysis, the framework enables more informed and dynamic maintenance strategies. The model incorporates a comprehensive approach that combines reliability assessment, economic analysis, and continuous re-evaluation to optimize maintenance, replacement, and life extension decisions. The optimization method on the base of genetic algorithm (GA) is employed to minimize total life cycle costs while maintaining component reliability within acceptable thresholds. The framework’s effectiveness is demonstrated through case studies on three distinct aircraft components: mechanical, avionics, and engine. These studies showcase the model’s versatility in handling different failure patterns and maintenance requirements. This study introduces a data-driven decision-making framework for optimizing the life cycle management of aircraft components, focusing on reliability, cost-effectiveness, and safety. To achieve optimal maintenance scheduling and resource allocation, a GA is employed, allowing for an effective exploration of complex solution spaces and enabling dynamic decision-making based on real-time data inputs. The GA-based optimization approach minimizes total life cycle costs while maintaining component reliability, with the framework’s effectiveness demonstrated through case studies on key aircraft components. Key findings from the case study demonstrate significant cost reductions through optimization, with mechanical components showing a 10% more reduction in total life cycle costs, avionics components achieving a 14% more cost reduction, and engine components demonstrating a 7% more decrease in total costs. The research also presents an optimized dynamic maintenance schedule that adapts to real-time component health data, extending component lifespans and reducing unexpected failures. The framework effectively addresses key industry challenges such as no fault found events while minimizing unexpected failures and enhancing the overall reliability and safety of aircraft maintenance practices. Sensitivity analysis further demonstrates the model’s robustness, showing stable performance under varying failure rates, maintenance costs, and degradation rates. The study contributes a scalable approach to predictive maintenance, balancing safety, cost, and resource allocation in dynamic operational environments.