Unified enantioselective capillary chromatography on a Chirasil-DEX stationary phase Advantages of column miniaturization

Schurig, Volker; Jung, Martin; Mayer, Sabine; Fluck, Markus; Negura, Simona; Jakubetz, Hansjörg

doi:10.1016/0021-9673(94)01075-p

Cited by 98 publications

(32 citation statements)

References 22 publications

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“…Yet the unified approach was met with success. 75 Hexobarbital is baseline enantioseparated by all four contemporary chromatographic methods on the same fused silica column [80 cm Â 0.05 mm (i.d.)] coated with 0.15 mm Chirasilb-Dex 9 (cf.…”

Section: Unified Enantioselective Open Tubular Capillary Chromatograpmentioning

confidence: 99%

“…75 As resolution of racemates represents only a binary separation system (unless enantiomers are determined in a complex matrix), the entire separation window offered by long capillary columns is not required. By employing a short column, the loss of efficiency, H, is outweighed by a gain of enantioselectivity, ÀD D,L DG, as the elution temperature can be reduced far below T isoenant .…”

Section: Column Miniaturization In Enantioselective Gcmentioning

confidence: 99%

“…capillary column. 75,76 A new example of the separation of a homologous series of racemates using a short 5 m Â 250 mm (i.d.) capillary column coated with Chirasil-b-Dex 9 is demonstrated in Figure 14.…”

Section: Column Miniaturization In Enantioselective Gcmentioning

confidence: 99%

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Contributions to the theory and practice of the chromatographic separation of enantiomers

Schurig

2005

Chirality

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The theory and practice of enantioselective capillary chromatography employing metal coordination compounds and modified cyclodextrins as chiral stationary phases are treated. A unified approach involving all contemporary chromatographic methods and a single enantioselective column is described. Reliable thermodynamic data of enantioselectivity are derived by the retention-increment method. The existence of an isoenantioselective temperature is demonstrated. Kinetic enantiomerization studies are presented. The preparative-scale separation of enantiomers by gas chromatography with enantioselective packed columns is achieved. Unusual phenomena and future aspects of enantioselective chromatography are discussed.

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Section: Unified Enantioselective Open Tubular Capillary Chromatograpmentioning

confidence: 99%

Section: Column Miniaturization In Enantioselective Gcmentioning

confidence: 99%

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Contributions to the theory and practice of the chromatographic separation of enantiomers

Schurig

2005

Chirality

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“…Chiral separations can be achieved by the use of chiral stationary phases [265][266][267][268][269][270], a chiral selector that is adsorbed on the packing material [265,271,272], or by using chiral mobile phase additives [265,[273][274][275]. For instance, W~nnman et al [265] reported on the separation of chiral ethanol and propanol derivatives on a Pirkle phase.…”

Section: Chiral Separationsmentioning

confidence: 99%

Microcolumn liquid chromatography: instrumentation, detection and applications

Vissers¹,

Claessens

Cramers

1997

Journal of Chromatography A

208

101

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This review discusses many different aspects of microcolumn liquid chromatography (LC) and reflects the areas of microcolumn LC research interest over the past decades. A brief theoretical discussion on a number of major issues, such as column characterisation, chromatographic dilution effects and extracolumn band broadening in microcolumn LC is given. Recent progress in column technology and the demands and developments of instrumentation and accessories for microcolumn LC are also reviewed. Besides that, the developments in a large number of established and also more recent detection techniques for microcolumn LC are also discussed. The potential of hyphenation of microcolumn LC with other techniques, more particularly of multidimensional chromatography and microcolumn LC coupled to mass spectrometry is reviewed. Finally, the perspective of microcolumn LC separation methods is stressed by a number of relevant applications.

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“…Benzodiazepines have also been successfully separated on etched cholesteryl modified capillary columns [19]. Schurig et al [20] showed the potential For open tubular columns to be recognised and accepted as robust alternatives to packed columns in CEC more work is still required, particularly on the separation of charged analytes which are of great interest and importance to the pharmaceutical and biological industry. This work therefore set out to investigate the applications of open tubular column for charged analytes.…”

Section: Introductionmentioning

confidence: 99%