It is well-known that several problems related to analysis on s-John domains can be unified by certain capacity lower estimates. In this paper, we obtain general lower bounds of pcapacity of a compact set E and the central Whitney cube Q 0 in terms of the Hausdorff q-content of E in an s-John domain Ω. Moreover, we construct several examples to show the essential sharpness of our estimates.2010 Mathematics Subject Classification. 30C65,46E35.