Uniform corrosion behavior of GZ51K alloy with long period stacking ordered structure for biomedical application

Zhang, Xiaobo; Ba, Zhixin; Wang, Qian; Wu, Yujuan; Wang, Zhangzhong; Wang, Qiang

doi:10.1016/j.corsci.2014.07.004

Cited by 94 publications

(33 citation statements)

References 26 publications

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“…-1.0 V vs. SHE for the J1 alloy compared with -1.5 V vs. SHE for pure Mg when measured in blood plasma. Furthermore, the fine Mg 17 Sr 2 particles obtained during aging were speculated to have played a role of inducing a homogeneous corrosion [47] on the surface of the J1 alloy as opposed to highly localized, pitting, and crevice corrosion reported for other Mg alloys [25,45,48]. As a result, at the conclusion of the 16w implantation, minor localized corrosion was observed on the surface of the J1 alloy (Fig.…”

Section: Discussionmentioning

confidence: 81%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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Section: Discussionmentioning

confidence: 81%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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“…Recently, we have studied the corrosion behavior of the Mg-5Gd-1Zn-0.6Zr (GZ51K) alloy in SBF under as-cast, solution-treated, and aging-treated conditions (Zhang , Ba, Wang, Wu, Wang, & Wang, 2014a). It was observed that the as-cast GZ51K alloy with LPSO structure exhibits better corrosion resistance and a more uniform corrosion mode than aging-treated alloys without LPSO structure.…”

Section: Heat Treatmentmentioning

confidence: 98%

“…The LPSO structure plays a very important role in the corrosion behavior of Mg alloys (Leng et al, 2013;Peng et al, 2014;Zhang, Wu, Xue, Wang, & Yang, 2012c;Zhang et al, 2014a;Zhang et al, 2015). Zhang et al (2012c) reported that corrosion rate of the as-extruded Mg-11.3Gd-2.5Zn-0.7Zr alloy with LPSO structure in SBF is only 0.17 mm/year, while that of the as-extruded Mg-10.2Gd-3.3Y-0.6Zr alloy without LPSO structure is 0.55 mm/year.…”

Section: The Improvement Of Corrosion Behavior By Lpso Structurementioning

confidence: 98%

Improvement of corrosion resistance of magnesium alloys for biomedical applications

Chen¹,

Dai²,

Zhang³

2015

Corrosion Reviews

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In recent years, magnesium (Mg) alloys have attracted great attention due to superior biocompatibility, biodegradability, and other characteristics important for use in biodegradable implants. However, the development of Mg alloys for clinical application continues to be hindered by high corrosion rates and localized corrosion modes, both of which are detrimental to the mechanical integrity of a load-bearing temporary implant. To overcome these challenges, technologies have been developed to improve the corrosion resistance of Mg alloys, among which surface treatment is the most common way to enhance not only the corrosion resistance, but also the bioactivity of biodegradable Mg alloys. Nevertheless, surface treatments are unable to fundamentally solve the problems of fast corrosion rate and localized corrosion. Therefore, it is of great importance to alter and improve the intrinsic corrosion behavior of Mg alloys for biomedical applications. To show the significance of the intrinsic corrosion resistance of biodegradable Mg alloys and attract much attention on this issue, this article presents a review of the improvements made to enhance intrinsic corrosion resistance of Mg alloys in recent years through the design and preparation of the Mg alloys, including purifying, alloying, grain refinement, and heat treatment techniques. The influence of long-period stacking-ordered structure on corrosion behavior of the biodegradable Mg alloys is also discussed.

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“…Zhang [13] reported that as-extruded Mg–11.3Gd–2.5Zn–0.7Zr (wt %) alloy with a lamellar LPSO phase exhibited better corrosion resistance and more uniform corrosion than Mg–10.2Gd–3.3Y–0.6Zr (wt %) alloy, wherein the LPSO phase was absent. By contrast, it was revealed by [14] that the lamellar LPSO structure along the grain boundary in as-cast Mg–5Gd–1Zn–0.6Zr (wt %) alloy can act as a barrier between the substrate and the eutectic phase and inhibit galvanic corrosion. In the Mg–Zn–Y alloys, the LPSO phase of 18R structure was obtained in the cast state which usually appeared in the crystal boundary, and turned to a 14H structure after heat treatment, which appeared laminated in the crystal.…”

Section: Introductionmentioning

confidence: 96%

The Effect of Rod-Shaped Long-Period Stacking Ordered Phases Evolution on Corrosion Behavior of Mg95.33Zn2Y2.67 Alloy

et al. 2018

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The morphology evolution of long-period stacking ordered (LPSO) phases on corrosion behavior of Mg95.33Zn2Y2.67 alloy is investigated systematically during as-cast, pre-extrusion heat-treated, as-extruded and post-extrusion heat-treated conditions. The second phases in the as-cast alloy are only LPSO phases with a few Y particles. The pre-extrusion heat treatment changed LPSO phases from blocks into a rudimentary rod shape with lamellar structure, subsequently into fine fragments by extrusion, and then into a regular rod shape with lamellar structure followed by post-extrusion heat treatment. Immersion tests and electrochemical measurements in 3.5 wt % NaCl solution reveal that the post-extrusion heat-treated alloy has the best corrosion resistance with the lowest corrosion rate. This is attributed to the rod-shaped LPSO phases, which could hinder corrosion proceeding, and result in corrosion orientated along the direction of rods and forming relatively dense long-strip corrosion products. Our findings demonstrate that the improved corrosion resistance of magnesium alloys with LPSO phases can be tailored effectively by the proceeding technology and post-heat treatment.

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Uniform corrosion behavior of GZ51K alloy with long period stacking ordered structure for biomedical application

Cited by 94 publications

References 26 publications

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

Improvement of corrosion resistance of magnesium alloys for biomedical applications

The Effect of Rod-Shaped Long-Period Stacking Ordered Phases Evolution on Corrosion Behavior of Mg95.33Zn2Y2.67 Alloy

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