Uniform Reduction of Scalar Coupling by Real‐Time Homonuclear J‐Downscaled NMR

Glanzer, Simon; Zangger, Klaus

doi:10.1002/cphc.201500640

Cited by 4 publications

(2 citation statements)

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“…In high resolution NMR this includes real-time heteronuclear J-scaling 22 (for which a detailed analysis of the effects of pulse imperfections has been presented), 23 real-time pure shi NMR, 8,9,12,14,15,19,24 and J-up-and down-scaling. [25][26][27] With one honorable exception, 14 such problems have largely been ignored in the literature.…”

Section: Resultsmentioning

confidence: 99%

Real-time broadband proton-homodecoupled CLIP/CLAP-HSQC for automated measurement of heteronuclear one-bond coupling constants

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Real-time broadband proton-homodecoupled CLIP/CLAP-HSQC for automated measurement of heteronuclear one-bond coupling constants

et al. 2016

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“…Frequent occurrence of such problems prevents the straightforward determination of couplings. As a partial redressal to this problem, several approaches are reported in real‐time data chunking scheme, namely, J ‐upscaling and J ‐downscaling . The reintroduction of selective couplings of interest in the pure shift experiments also paves the way for the easy extraction of accurate coupling ( J ) strengths …”

Section: Spin–spin Couplings and Their Reintroductionmentioning

confidence: 99%

Orchestrated approaches using pure shift NMR: Extraction of spectral parameters, ultra‐high resolution, and sensitivity enhancement

Mishra

Suryaprakash

2018

Magnetic Reson in Chemistry

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The limited chemical shift range of protons and pairwise interaction among all the abundant nuclear spins of a molecule makes H spectrum too complicated. As a consequence, the straightforward analysis and the accurate extraction of their interaction strengths from the H spectrum of a complex spin system are formidably difficult or often impossible. This problem persists in the determination of scalar couplings be it between two abundant homonuclear spins or between H and an abundant heteronuclear spin (viz., F and P). Such problems are encountered in many situations where the determination of homonuclear and heteronuclear couplings is challenging. The several pure shift based one-dimensional and two-dimensional NMR strategies recently developed in our laboratory for the straightforward extraction of homonuclear and heteronuclear interaction parameters in diverse situations are discussed. Initially, the unique application of pure shift technique that paves the way for easy and straightforward extraction of magnitudes of heteronuclear couplings, namely, J (where X stands for F, P, etc.), is discussed. Subsequently, several pure shift edited one-dimensional and two-dimensional NMR strategies that are developed for the direct extraction of homonuclear and heteronuclear couplings and for achieving ultra-high-resolved H spectra with complete eradication of zero frequency peaks and the evolution of unwanted couplings. The enhancement in the sensitivity has also been achieved in the slice-selective pure shift experiments by the rapid acquisition of proton spectrum where the polarization from the adjacent protons is transferred to the selectively excited proton.

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