Let M be a Riemannian manifold with a smooth boundary. The main question we address in this article is: “When is the Laplace–Beltrami operator Δ:Hk+1false(Mfalse)∩H01false(Mfalse)→Hk−1false(Mfalse), k∈double-struckN0, invertible?” We consider also the case of mixed boundary conditions. The study of this main question leads us to the class of manifolds with boundary and bounded geometry introduced by Schick (Math. Nachr. 223 (2001), 103–120). We thus begin with some needed results on the geometry of manifolds with boundary and bounded geometry. Let ∂DM⊂∂M be an open and closed subset of the boundary of M. We say that (M,∂DM) has finite width if, by definition, M is a manifold with boundary and bounded geometry such that the distance dist(x,∂DM) from a point x∈M to ∂DM⊂∂M is bounded uniformly in x (and hence, in particular, ∂DM intersects all connected components of M). For manifolds (M,∂DM) with finite width, we prove a Poincaré inequality for functions vanishing on ∂DM, thus generalizing an important result of Sakurai (Osaka J. Math, 2017). The Poincaré inequality then leads, as in the classical case to results on the spectrum of Δ with domain given by mixed boundary conditions, in particular, Δ is invertible for manifolds (M,∂DM) with finite width. The bounded geometry assumption then allows us to prove the well‐posedness of the Poisson problem with mixed boundary conditions in the higher Sobolev spaces Hsfalse(Mfalse), s≥0.