Uniform shell designs for optimization in reversed-phase liquid chromatography

Hu, Yuzhu; Massart, D.L.

doi:10.1016/s0021-9673(01)89146-9

Cited by 62 publications

(16 citation statements)

References 8 publications

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“…and the number of parameters to be estimated from the fitted multiple linear-quadratic regression equation is equal to (d + 1) (d + 2)/2 (Hu and Massart, 1989). In our HS-SPME optimization study, there are a total of 4 2 + (4 + 1) = 21 + 3 center point replicates = 24 points in the complete Doehlert design and (4 + 1) (4 + 2)/2 = 15 parameters to be estimated from multiple linearquadratic regression, as expressed in the following equation:…”

Section: Doehlert Optimizationmentioning

confidence: 99%

Optimization of a novel headspace–solid‐phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

DiCicco

Láng

Harper

2009

Biomedical Chromatography

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Medical devices sterilized by ethylene oxide (EtO) retain trace quantities of EtO residuals, which may irritate patients' tissue. Reliably quantifying trace level EtO residuals in small medical devices requires an extremely sensitive analytical method. In this research, a Doehlert uniform shell design was utilized in obtaining a response surface to optimize a novel headspace-solid-phase microextraction-gas chromatographic (HS-SPME-GC) method developed for analyzing trace levels of EtO residuals in sterilized medical devices, by evaluating sterilized, polymer-coated, drug-eluting cardiovascular stents. The effects of four independent experimental variables (HS-SPME desorption time, extraction temperature, GC inlet temperature and extraction time) on GC peak area response of EtO were investigated simultaneously and the most influential experimental variables determined were extraction temperature and GC inlet temperature, with the fitted model showing no evidence of lack-of-fit. The optimized HS-SPME-GC method demonstrated overall good linearity/linear range, accuracy, repeatability, reproducibility, absolute recovery and high sensitivity. This novel method was successfully applied to analysis of trace levels of EtO residuals in sterilized/aerated cardiovascular stents of various lengths and internal diameter, where, upon heating, trace EtO residuals fully volatilized into HS for extraction, thereby nullifying matrix effects. As an alternative, this novel HS-SPME-GC method can offer higher sensitivity compared with conventional headspace analyzer-based sampling.

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Section: Doehlert Optimizationmentioning

confidence: 99%

Optimization of a novel headspace–solid‐phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

DiCicco

Láng

Harper

2009

Biomedical Chromatography

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“…The main advantages of the use of multivariate methods are the necessity of fewer experiments, reducing cost and time, and the possibility to obtain information about interaction between variables, which is not possible in univariate optimization. Most popular multivariate strategies are based on response surface methodology (RSM), which is a multivariate technique that fits, mathematically, the experimental domain in the theoretical design by use of a response function [28,29]. In this field, second-order designs like Central Composite, Box-Behnken or Doehlert matrix have been employed to establish the mathematical relationship (model) among factors (experimental variables in the levels tested) and experimental response [30].…”

Section: Introductionmentioning

confidence: 99%

Polyurethane foam loaded with SDS for the adsorption of cationic dyes from aqueous medium: Multivariate optimization of the loading process

Robaina

Soriano

Cassella

2009

Journal of Hazardous Materials

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“…They need fewer experiments, which are more efficient and can moved through the experimental field, and points obtained from a previous design could be used in later designs when they are adjacent [15]. In addition, the quantity of the levels related to each factor can be selected in order to obtain more information about significant or problematic factors [16].…”

Section: Introductionmentioning

confidence: 99%

Use of factorial design and Doehlert matrix for multivariate optimisation of an on-line preconcentration system for lead determination by flame atomic absorption spectrometry

et al. 2003

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A system for on-line preconcentration and determination of lead by flame atomic absorption spectrometry (FAAS) was proposed. It was based on the sorption of lead(II) ions on a minicolumn of polyurethane foam loaded with 2-(2-thiazolylazo)-5-dimethylaminophenol (TAM). The optimisation step was carried out using two-level full factorial and Doehlert designs for the determination of the optimum conditions for lead preconcentration. The proposed procedure allowed the determination of lead with a detection limit of 2.2 microg L(-1), and a precision, calculated as relative standard deviation (RSD), of 2.4 and 6.8 for a lead concentration of 50.0 and 10.0 microg L(-1), respectively. A preconcentration factor of 45 and a sampling frequency of 27 samples per hour were obtained. The recovery achieved for lead determination in the presence of several cations demonstrated that this procedure has enough selectivity for analysis of environmental samples. The validation was carried out by analysis of certified reference material. This procedure was applied to lead determination in natural food.

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Uniform shell designs for optimization in reversed-phase liquid chromatography

Cited by 62 publications

References 8 publications

Optimization of a novel headspace–solid‐phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

Optimization of a novel headspace–solid‐phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

Polyurethane foam loaded with SDS for the adsorption of cationic dyes from aqueous medium: Multivariate optimization of the loading process

Use of factorial design and Doehlert matrix for multivariate optimisation of an on-line preconcentration system for lead determination by flame atomic absorption spectrometry

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