In this work, we prove the local well-posedness of strong solutions to the isentropic compressible Navier-Stokes-Maxwell system with vacuum in a smooth, simply connected and bounded domain Ω ⊂ R. KEYWORDS isentropic, LWP, Navier-Stokes-Maxwell, vacuum MSC CLASSIFICATION 35Q30; 35Q35; 35B25 Math Meth Appl Sci. 2020;43:5357-5368. wileyonlinelibrary.com/journal/mma © 2020 John Wiley & Sons, Ltd. 5357 FAN ET AL.We will assume the following compatibility condition:This model is a coupled system of equations consisting the Lorentz force in the fluid equation and the electric current in the Maxwell equations. Equation (1.3) is called the Ampere-Maxwell equation, which has essential different structure with the majority of magnetohydrodynamics models. According to classical quasi-neutrality assumption, most of mathematicians consider the Maxwell's system as a parabolic equation for the magnetic field b. However, we keep the hyperbolic nature of Maxwell equation, which brings difficulty to analyze the existence. Regarding the incompressible case, the existence, regularity criteria, and long-time behavior has been studied by several studies. [3][4][5][6] To the authors' best knowledge, there are few results at compressible case. When = 0, Equations (1.1) and (1.2) reduce to the well-known isentropic compressible Navier-Stokes system, Gong et al 7 and Huang 8 showed the local well-posedness of strong solutions without Equation (1.8).When inf 0 > 0, the problem has received many studies. Jiang and Li 9-11 studied the vanishing limit of dielectric constant 1 . Fan et al [12][13][14] considered the vanishing limits of dielectric constant 1 or the Mach number 2 . Chen et al 15 and Mi and Gao 16 established the long-time asymptotic behavior of the smooth solutions.When inf 0 = 0, Fan and Jia 17 showed the local-posedness of strong solutions under Equation (1.8). The aim of this paper is to prove a similar result without Equation (1.8). We will proveThen the problem has a unique local strong solution ( , u, E, b) satisfyingHow to cite this article: Fan J, Jing L, Nakamura G, Tang T. Local well-posedness of the isentropic Navier-Stokes-Maxwell system with vacuum. Math Meth Appl Sci. 2020;43:5357-5368. https://doi.