Unilateral acute posterior multifocal placoid pigment epitheliopathy in a convalescent COVID-19 patient

Olguín-Manríquez, Francisco; Cernichiaro-Espinosa, Linda A.; Olguín-Manríquez, Arturo; Manríquez-Arias, Rebeca; Flores-Villalobos, Erick Omar; Kawakami-Campos, Perla Ayumi

doi:10.1186/s40942-021-00312-w

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Posterior placoid maculopathy has been documented in association with many diseases including ocular syphilis, COVID-19, vasculitis, serpiginous choroiditis, birdshot retinochoroidopathy, and acute posterior multifocal placoid pigment epitheliopathy. 4 , 6 , 7 To our knowledge, this is the first documented case of posterior placoid-like maculopathy with macular hole secondary to VAD.…”

Section: Discussionmentioning

confidence: 73%

Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency

Lai

Dinh

Brian

et al. 2023

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 73%

Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency

Lai

Dinh

Brian

et al. 2023

American Journal of Ophthalmology Case Reports

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“…Colour fundus photographs showed multiple yellow-white placoid lesions involving the fovea in the right eye. Investigations were consistent with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in a convalescent COVID-19 patient [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Use of Imaging Technology to Assess the Effect of COVID-19 on Retinal Tissues: A Systematic Review

McGrath

Aslam

2022

Ophthalmol Ther

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Purpose To evaluate the effect of COVID-19 on retinal tissues by conducting a systematic review and meta-analysis of the current literature. Background The novel coronavirus disease is not yet well understood. The orbit provides a window into the body's microvasculature, and as such, it is a non-invasive opportunity to analyse the systemic circulation in vivo. By analysing the current literature, we test the hypothesis that non-invasive imaging of the retina could provide insight into the effect of COVID-19 on the retinal microvasculature. Methods For this systematic review and meta-analysis, we screened PubMed databases and LitCOVID19 using the search criteria: (OCTA or Optical Coherence Tomography Angiography) AND (COVID-19 or corona or SARS-CoV-2) AND (retina or fundus). Databases were searched on 11 January 2022. The primary study outcomes were studies that utilised OCTA to analyse the retina; secondary outcomes involved studies that involved other imaging modalities such as OCT, fundus photography, and fundus autofluorescence. Findings The total number of studies included in this review was 32. Optical coherence tomography angiography scans show reduced central retinal vascular density, a thinner ganglion cell layer, a thicker retinal nerve fibre layer, and an enlarged foveal avascular zone. Optical coherence tomography scans demonstrate a thicker central macular thickness and other changes to the macula, ganglion cell, and inner nuclear layers. Many fundus photographs depicted cotton wool spots, microhaemorrhages, and vascular occlusions. Non-invasive imaging technology has demonstrated that COVID-19 can profoundly affect the retina. Therefore, there is a requirement for long-term follow-up of COVID-19 patients to assess whether the retinal damage caused by COVID-19 is reversible. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-022-00509-8.

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“…There have been several reports of APMPPE associated with COVID-19 infection or vaccination. Olguín et al reported a case of APMPPE developing 2 weeks after a COVID-19 infection [20]. Atas et al reported a case of APMPPE after a rst COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

A case of APMPPE-like panuveitis presenting with extensive outer retinal layer impairment following COVID-19 vaccination

Ogino

Namba

Iwata

et al. 2022

Preprint

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Background Vaccination against the worldwide pandemic coronavirus disease 2019 (COVID-19) is underway; however, some cases of newly onset uveitis after vaccination have been reported. We report a case of bilateral acute posterior multifocal placoid pigment epitheliopathy-like (AMPPE-like) panuveitis after COVID-19 vaccination in which the patient’s pathological condition was evaluated using multimodal imaging. Case presentation A 31-year-old woman experienced bilateral hyperemia and blurred vision starting 6 days after her second inoculation of the COVID-19 vaccination. At her first visit, her visual acuity was decreased bilaterally, and severe bilateral anterior chamber inflammation and bilateral scattering of cream-white placoid lesions on the fundus were detected. Optical coherence tomography (OCT) showed serous retinal detachment (SRD) and choroidal thickening in both eyes (OU). Fluorescein angiography (FA) revealed hypofluorescence in the early phase and hyperfluorescence in the late phase corresponding to the placoid legions. Indocyanine green angiography (ICGA) showed sharply marginated hypofluorescent dots of various sizes throughout the mid-venous and late phases OU. The patient was diagnosed with APMPPE and was observed without any medications. Three days later, her SRD disappeared spontaneously. However, her anterior chamber inflammation continued, and oral prednisolone (PSL) was given to her. Seven days after the patient’s first visit, the hyperfluorescent lesions on FA and hypofluorescent dots on ICGA partially improved; however, the patient’s best corrected visual acuity (BCVA) dropped to 0.7 OD and 0.6 OS, and the impairment of the outer retinal layer was broadly detected as hyperautofluorescent lesions on fundus autofluorescence (FAF) examination and as irregularity in or disappearance of the ellipsoid and interdigitation zones on OCT, which were quite atypical for the findings of APMPPE. Steroid pulse therapy was performed. Five days later, the hyperfluorescence on FAF had disappeared, and the outer retinal layer improved on OCT. Moreover, the patient’s BCVA recovered to 1.0 OU. Twelve months after the end of treatment, the patient did not show any recurrences. Conclusions We observed a case of APMPPE-like panuveitis after COVID-19 vaccination featuring some atypical findings for APMPPE. COVID-19 vaccination may induce not only known uveitis but also atypical uveitis, and appropriate treatment is required for each case.

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Unilateral acute posterior multifocal placoid pigment epitheliopathy in a convalescent COVID-19 patient

Cited by 21 publications

References 12 publications

Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency

Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency

Use of Imaging Technology to Assess the Effect of COVID-19 on Retinal Tissues: A Systematic Review

A case of APMPPE-like panuveitis presenting with extensive outer retinal layer impairment following COVID-19 vaccination

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