Unilateral Anophthalmia and Congenital Frontal Cranioschisis Associated with Extradural Neuroglial Heterotopia: new Insights into a Possible New Malformative Spectrum

Montero, Javier Arredondo; Anaut, Mónica Bronte; Pascual, Carlos Bardají

doi:10.1080/15513815.2022.2086330

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Moreover, serum NSE testing was omitted during the follow-up period. Immunohistochemically, NSE exhibited positive expression, aligning with findings in similar cases ( 5 , 7 , 11 , 15 ). Histologically, neuroglial heterotopia is characterized by mature astrocytes and glial fibers within a fibrovascular stroma, along with rare components like neurons, choroid plexus, and oligodendrocytes.…”

Section: Discussionsupporting

confidence: 86%

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Retroperitoneal neuroglial heterotopia: a case report and literature review

Zhong,

Yang,

Lin

et al. 2024

Front. Pediatr.

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BackgroundNeuroglial heterotopia is a rare lesion composed of differentiated neuroectodermal cells that manifest in extracranial locations, with the majority of cases predominantly occurring in the head and neck region. Retroperitoneal neuroglial heterotopia is exceptionally rare, with isolated cases published in the scientific literature.Case reportHere, we present the case of a 3-year-old girl who was admitted without clinical signs but presented with a palpable abdominal mass. Ultrasonography and computed tomography scans revealed a sizable cystic lesion within the retroperitoneal space. Subsequently, laparoscopic resection was performed. Histological examination unveiled neuroglial cell-lined cysts encompassing fibrous connective tissue, ganglia, glial tissue, and nerve bundles. Notably, distinct areas and cell types exhibited expression of S100, glial fibrillary acidic protein, and neuron-specific enolase. Follow-up assessments revealed no relapses or late complications.ConclusionIn cases of retroperitoneal neuroglial heterotopia, most children may remain asymptomatic without any congenital anomalies. Despite their detectability through imaging, accurate preoperative diagnosis is seldom achieved. Generally, a favorable prognosis follows complete surgical resection, although further cases are required to confirm its long-term efficacy, necessitating extended follow-up for verification.

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Section: Discussionsupporting

confidence: 86%

“…While the preoperative serum NSE level was elevated in our case, this phenomenon was not observed in other cases ( 1 – 15 ). We explored the potential correlation between this elevation in NSE and the size of the mass, considering our case is the largest documented to date.…”

Section: Discussioncontrasting

confidence: 68%

Retroperitoneal neuroglial heterotopia: a case report and literature review

Zhong,

Yang,

Lin

et al. 2024

Front. Pediatr.

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“…In our experience, an adequate and systematic organization allows the recording and documentation of clinical cases of relevance without compromising the pace of work or the quality of care. [2][3][4] In cases in which a histological study-which was not possible in the field-was needed, we transferred the specimens to Spain and processed them in our center. This was not only essential to confirm the diagnosis to provide follow-up care to patients, but also allowed us to document the cases in depth to share our results in peer-reviewed scientific journals.…”

mentioning

confidence: 99%

Cooperation and Scientific Contribution: The Search for a Common Nexus

Montero

Anaut

Martín‐Calvo

et al. 2023

Clin Pediatr (Phila)

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International cooperation in pediatrics and pediatric surgery entails important barriers such as sociocultural differences, language difficulties, lack of infrastructure and resources, and short duration of campaigns. In this work, we share our personal experience in relation to the scientific publication of works carried out in pediatric international cooperation, and we make a critical reflection on the aspects to be considered for this field to develop in the future.

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Unilateral Anophthalmia and Congenital Frontal Cranioschisis Associated with Extradural Neuroglial Heterotopia: new Insights into a Possible New Malformative Spectrum

Cited by 2 publications

References 13 publications

Retroperitoneal neuroglial heterotopia: a case report and literature review

Retroperitoneal neuroglial heterotopia: a case report and literature review

Cooperation and Scientific Contribution: The Search for a Common Nexus

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