Unilateral Areolar Sebaceous Hyperplasia in a Male

Abstract

We report a case of areolar sebaceous hyperplasia involving the right mammary areola in a 49-year-old male. Areolar sebaceous hyperplasia, an uncommon entity first described by Catalano and Ioannides in 1985, is characterized clinically by yellowish thickening of the areolae and histopathologically by large numbers of mature hyperplastic sebaceous lobules connected to the skin surface through short, hairless infundibular canals. Since its original description, only two additional reports have been published. To our knowledge, our patient is the first reported of areolar sebaceous hyperplasia in a male.

Areolar Sebaceous Hyperplasia With Underlying Primary Duct Carcinoma of the Breast in a Woman With Donohue Syndrome (Leprechaunism)

“…35 This is primarily the reason why some consider areolar sebaceous hyperplasia to be a malformation. 5,9 In our case, a tumoral pathology was obviously underneath the hyperplasia, and one wonders if the latter could have been induced by the former. Cases of sebaceous hyperplasia have been reported over cutaneous tumors, such as dermatofibromas.…”

“…[1][2][3][4][5][6][7][8][9][10][11] We have also not found any case of association of areolar sebaceous hyperplasia and ipsilateral breast carcinoma. Glazebrook et al 33 described 2 cases in which breast carcinoma mimicked an areolar dermal lesion on sonography, but this appearance was due to dermal infiltration by the carcinoma, whereas the histopathologic study demonstrated no adnexal or epidermal alterations.…”

“…1 This type of phenomenon could be related to a hyperplasia of the Montgomery tubercles, which is common in women after delivery and during lactation. 34 However, many of the reported cases of areolar sebaceous hyperplasia appeared in men, 5,[7][8][9]32 and according to some, men lack Montogomery tubercles. 35 This is primarily the reason why some consider areolar sebaceous hyperplasia to be a malformation.…”

“…We have found 12 cases published in the literature, both in women and men. [1][2][3][4][5][6][7][8][9][10][11] Most of these cases were not associated with any relevant pathology.…”

Rare presentation of sebaceous hyperplasia

“…Some authors describe hyperplasia of Montgomery tubercles13; others describe hyperplasia of sebaceous glands unrelated to the Montgomery tubercles 9 11 12. In the present case, Montgomery tubercles were observed; therefore, we agree with Fariña et al 13 regarding the possible origin of this type of hyperplasia. However, cases have been reported in men,13 14 who according to some experts do not have Montgomery tubercles 21.…”