Unilateral Capecitabine-related Hand-foot Syndrome

Matsuda, Shuntaro; Koketsu, Hideki; Hayakawa, Manabu; Nagata, Naoto

doi:10.2169/internalmedicine.54.4920

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…Such disuse of the affected limb might decrease mechanical stress on the affected hand and HFS might not be observed in this patient. Unilateral HFS cases resembling our case were previously reported (16)(17)(18). In each case, they are hemiplegic patients after cerebral stroke and developed HFS on the intact-sided hand and foot only.…”

Section: Case Reportsupporting

confidence: 74%

Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report

et al. 2021

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Hand-foot syndrome (HFS) is a frequent adverse effect of various anti-tumour drugs, such as capecitabine, that affects their dose-limiting toxicity. The mechanism of HFS remains unknown and there are currently no effective strategies to treat HFS, except for cessation. The current study presented a female case where one hand, affected by brachial plexus infiltration due to the subclavian lymph node metastasis of breast cancer, exhibited not only pain and partial motor paralysis but also anhidrosis, oedema and skin colour changes. The patient met the diagnostic criteria for complex regional pain syndrome (CRPS). After treatment with capecitabine, their anhidrosis hand completely prevented HFS. The other hand and both feet demonstrated typical symptoms of HFS, which improved consequent to capecitabine cessation. The CRPS-affected hand remained normal. Considering the limited presentation of HFS concomitant with anhidrosis, the exocrine release of condensed capecitabine through sweat glands might be a promising mechanism of HFS induction.

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Section: Case Reportsupporting

confidence: 74%

Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report

et al. 2021

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“…Panitumab (P-XELOX) can be combined with oxaliplatin and oral capecitabine to treat colon cancer and advanced liver metastases [111]. Matsuda et al have found that after treatment with capecitabine, oxaliplatin and bevacizumab in patients with liver metastases with advanced colon cancer, symptoms of hand-foot syndrome (HFS) have emerged [112,113]. Simvastatin combined with irinotecan could overcome the resistance of irinotecan, and the combination of the two in a molar ratio of 2:1 can achieve the best effect to treat colon cancer [114].…”

Section: Western Medicinementioning

confidence: 99%

Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

Li¹,

Han²,

Zhang³

et al. 2019

Open J Proteom Genom

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Colon cancer is a common gastrointestinal malignancy in daily life and is the third most common cancer. So far, the global incidence of colon cancer has risen every year. Colon cancer mortality accounts for half of the incidence, colon cancer mortality ranks fi fth in malignant tumor mortality, which seriously threatens human survival and health. This article refers to the latest domestic and foreign related articles related to colon cancer. It summarizes common and emerging screening methods for colon cancer which can make early detection and early treatment of the disease for reducing the deterioration and metastasis of colon cancer. It discusses the diagnostic markers of colon cancer found out in recent years and its mechanism of action, to improve the level, accuracy and scientifi city of diagnosis. This article points out that the metastasis of colon cancer is the main cause of death in patients with colon cancer and to discuss the mechanism of its metastasis. It also summarizes the therapy thereof and advantages and disadvantages of colon cancer from different aspects such as intestinal fl ora, targeted therapy, traditional Chinese medicine and western medicine. Finally, the article summaries some methods that can effectively prevent colon cancer, reduce the occurrence of colon cancer from the source and improve people's quality of life.

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“…(f) A 60-year-old man with a history of cerebral infarction [9] was subsequently diagnosed to have multiple liver metastases of advanced descending colon cancer, based on the findings of computed tomography. His physical examination showed hemiplegia of the right upper and lower limbs.…”

Section: Case Reportsmentioning

confidence: 99%

Asymmetric Acral Spared Phenomenon Related to Systemic Anticancer Therapies

Baran

Robert

Sibaud

2018

Skin Appendage Disord

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We have observed three patients on anticancer therapies presenting with asymmetric acral spared phenomenon and found six identical cases in the literature. All of them had common features, an alteration of the peripheral nerves affecting a limb unilaterally that was spared by a hand-foot syndrome or hand-foot skin reaction. A drug-induced neurotropic effect sounds logical for developing such alterations with specific chemotherapeutic agents (taxanes, capecitabine), while we have not found good explanations concerning the multikinase inhibitor sorafenib nor the topo isomerase inhibitor adriamycin. Nevertheless, we know that clinical manifestations of many inflammatory diseases need intact neural components.

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Unilateral Capecitabine-related Hand-foot Syndrome

Cited by 7 publications

References 2 publications

Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report

Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report

Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

Asymmetric Acral Spared Phenomenon Related to Systemic Anticancer Therapies

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