Unilateral development of ovarian tumour in thymectomized Swiss mice following a single injection of 7,12-dimethylbenz(a)anthracene at neonatal stage

Shisa, Hayase; Nishizuka, Yasuaki

doi:10.1038/bjc.1968.10

Cited by 14 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent studies have shown that the administration of DMBA by oral (Biancifori et al, 1961;Jull et al, 1966;Krarup, 1967), intraperitoneal (Krarup, 1967), intravenous (Jull, 1969), or sUbcutaneous routes (Shisa and Nishizuka, 1968) will cause ovarian tumors in mice. Even direct application of DMBA to the ovary has induced tumors (Krarup, 1969).…”

mentioning

confidence: 99%

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity

Smith

Mattison

Sipes

1990

Toxicology and Applied Pharmacology

113

View full text Add to dashboard Cite

mentioning

confidence: 99%

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity

Smith

Mattison

Sipes

1990

Toxicology and Applied Pharmacology

113

View full text Add to dashboard Cite

“…The reason for this ultimate unilateral development may be found in changes in the hormonal balance (Shisa and Nishizuka, 1968). The role of overstimulation by pituitary gonadotrophins for the development of the tumours has been described after X-irradiation (Miihlbock, 1953) and intrasplenic ovary transplantation (Biskind and Biskind, 1944;Biskind et al, 1953;Lipschutz et al, 1964).…”

Section: Histogenesis Of Ovarian Tumoursmentioning

confidence: 99%

“…THE carcinogenic hydrocarbon 9,10-dimethyl-1,2-benzanthracene (DMBA) administered to sensitive strains of mice affects the ovaries and induces granulosa cell tumours regardless of whether it is applied externally to the skin (Howell et al, 1954;Marchant, 1957; Mody, 1960), orally (Biancifiori et al, 1961;Jull et al, 1966;Krarup, 1967;Kuwahara, 1967), intraperitoneally (Krarup, 1967;Kuwahara, 1967), intravenously (Kuwahara, 1967), subcutaneously (Shisa and Nishizuka, 1968), or directly to the surface of the ovary (Krarup, 1969a).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

Krarup¹

1970

Br J Cancer

View full text Add to dashboard Cite

SUMMARY.-Groups of immature and mature mice were treated once with DMBA by oral or intraperitoneal route, and the subsequent bilateral sequence of ovarian changes leading to the development of unilateral granulosa cell tumour was studied.Early post-treatment changes included disappearance of oocytes and follicles as well as increase of the stroma mass. The neoplastic development was closely correlated to the rate of oocyte disappearance. The faster oocytes were eliminated, the earlier tumours appeared. The early post-treatment changes led to a stage of potential preneoplasia, characterized by diffuse luteinization of the ovarian parenchyma. In some preneoplastic ovaries the luteinized tissue underwent neoplastic transformation and developed into invasive luteoma. In other preneoplastic ovaries foci of granulosa-like tumour cells appeared in the luteinized tissue, representing the stage of microscopic granulosa cell tumour. However, such microtumours could also develop within pre-existing luteomata. Autoradiography after injection of thymidine-3H suggested that the granulosa-like tumour cells developed as the result of undifferentiated proliferation of luteinized cells.So far the pathological ovarian evolution occurred bilaterally as well as unilaterally. However, when a microscopic granulosa cell tumour by further growth became a macroscopic granulosa cell tumour the contralateral ovary invariably atrophied. This ultimate unilateral development coincided with a continuous production of oestrogen by the granulosa cell tumour. The reason for the contralateral atrophy is discussed in relation to the influence of the hormonal balance on ovarian tumorigenesis. THE carcinogenic hydrocarbon 9,10-dimethyl-1,2-benzanthracene (DMBA) administered to sensitive strains of mice affects the ovaries and induces granulosa cell tumours regardless of whether it is applied externally to the skin (Howell et al

show abstract

Effects of carcinogen and/or mutagen on normal and gonadotropin‐primed ovaries of mice

1981

Intl Journal of Cancer

View full text Add to dashboard Cite

The influence of pregnant mare serum gonadotropin (PSGM) on the induction of ovarian tumors by carcinogen(DMBA) and/or mutagens (EMS and BMS) has been studied in Swiss albino mice. Priming of the ovaries of 6-week-old mice with PMSG (50 IU/mouse) 24 h before intragastric intubation of DMBA (5 mg/mouse) resulted in a significant increase in ovarian tumors when harvested 6 months after the treatment. A similar experiment done on 8-week-old mice yielded confirmatory results. Mutagens (EMS and BMS) failed, at given dose levels (200 mg/kg and 300 mg/kg body weight), to induce tumors in normal as well as PMSG-primed ovaries. Pretreatment of animals with PMSG-enhanced DMBA-induced oocyte depletion and also increased the DMBA-3H activity in the ovaries. The augmentation of DMBA-induced tumors in PMSG-primed ovaries could be due to increased uptake of DMBA and increased depletion of oocytes. It is also possible that PMSG-primed ovaries provided more proliferating granulosa cells (and macromolecules) for the interaction of DMBA (or its metabolites) and thereby increased the chances of cell transformation in the ovaries.

show abstract

Unilateral development of ovarian tumour in thymectomized Swiss mice following a single injection of 7,12-dimethylbenz(a)anthracene at neonatal stage

Abstract: Images Figs. 1-2

Cited by 14 publications

References 7 publications

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity

Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

Effects of carcinogen and/or mutagen on normal and gonadotropin‐primed ovaries of mice

Contact Info

Product

Resources

About