Unilateral hippocampal wasting after combined-modality therapy for glioblastoma

Seibert, Tyler M.; Dalia, Yoseph; Karunamuni, Roshan; Piccioni, David; McDonald, Carrie R.; Farid, Nikdokht; Hattangadi‐Gluth, Jona A.

doi:10.1080/0284186x.2017.1398412

Cited by 3 publications

(1 citation statement)

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“…Finally, radiation damage to the brain can evolve over time. A case report of a patient with glioblastoma showed unilateral hippocampal wasting that started shortly after completion of chemoradiation, then stabilized after six months (with follow-up to 20 months) 49 . While longitudinal trends for amygdala volume loss have not yet been reported, it is plausible that amygdala volumes can also change over time, and this should be investigated in future work.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent atrophy of the amygdala after radiotherapy

Huynh‐Le

Karunamuni

Moiseenko

et al. 2019

Radiotherapy and Oncology

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Background and Purpose: The amygdalae are deep brain nuclei critical to emotional processing and the creation and storage of memory. It is not known whether the amygdalae are affected by brain radiotherapy (RT). We sought to quantify dose-dependent amygdala change one year after brain RT. Materials and Methods: 52 patients with primary brain tumors were retrospectively identified. Study patients underwent high-resolution, volumetric magnetic resonance imaging before RT and 1 year afterward. Images were processed using FDA-cleared software for automated segmentation of amygdala volume. Tumor, surgical changes, and segmentation errors were manually censored. Mean amygdala RT dose was tested for correlation with amygdala volume change 1 year after RT via the Pearson correlation coefficient. A linear mixed-effects model was constructed to evaluate potential predictors of amygdala volume change, including age, tumor hemisphere, sex, seizure history, and bevacizumab treatment during the study period. As 51 of 52 patients received chemotherapy, possible chemotherapy effects could not be studied. A two-tailed p-value <0.05 was considered statistically significant. Results: Mean amygdala RT dose (r=−0.28, p=0.01) was significantly correlated with volume loss. On multivariable analysis, the only significant predictor of amygdala atrophy was radiation

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Section: Discussionmentioning

confidence: 99%