Unilateral injury of posterior parietal cortex and spatial learning in hooded rats

McDaniel, William F.; Via, J.D.; Smith, Jeffrey S.; Wells, Deborah L.; Fu, Junmin; Bishop, Julie; Boyd, P.A.; Ledesma, H.M.

doi:10.1016/0166-4328(95)80006-9

Cited by 33 publications

(25 citation statements)

References 38 publications

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“…This finding appears inconsistent with previous studies which have implicated the parietal lobe in egocentric spatial memory (e.g. Berthoz, 1997;McDaniel, Via, Smith et al, 1995;Save and Moghaddam, 1996). However, focal damage is much more likely to cause serious disruption of neural circuits than atrophy and our results do not exclude the possibility that more focal lesions to the right areas of the parietal cortex would cause such a memory impairment.…”

Section: Discussioncontrasting

confidence: 56%

“…(4) RS's lateral and third ventricles were enlarged which may suggest damage to diencephalic structures such as the thalamus. Surprisingly, there was no evidence that RS had more atrophy than NM to the brain regions which have been previously associated with egocentric spatial processing in the animal literature, that is, the frontal cortex and parietal cortex (Fuster, 1980;McDaniel, Via, Smith et al, 1995;Niki, 1975;Pohl, 1973;Semmes et al, 1963). In fact, RS had much less atrophy to the parietal lobe than NM who was unimpaired on the egocentric task.…”

Section: Discussionmentioning

confidence: 94%

“…This latter finding is particularly relevant given the proposed role of the parietal cortex in egocentric spatial processing (e.g. Anderson, 1997;Berthoz, 1997;Karnath, 1997;McDaniel, Via, Smith et al, 1995;Save and Moghaddam, 1996). RS also had enlarged lateral and third ventricles whereas NM's ventricle volumes did not differ significantly from the control mean volume (see Table III).…”

Section: Fig 1 -Coronal Sections From the Patients Rs Nm And An Agmentioning

confidence: 89%

“…Korsakoff's syndrome has been recently found to result in dysfunction to a number of brain structures (Kopelman, 1995;Paller et al, 1997) beyond those observed in the classic neuropathology. PET has revealed pathology of the frontal and parietal cortices of Korsakoff patients (Paller et al, 1997) and both of these regions have been implicated in egocentric spatial processing (Fuster, 1980;McDaniel, Via, Smith et al, 1995;Niki, 1975;Pohl, 1973;Save and Moghaddam, 1996;Semmes et al, 1963). This may account for the egocentric memory deficit.…”

Section: Discussionmentioning

confidence: 99%

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A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage

et al. 2000

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Two patients with medial temporal lobe damage, seven Korsakoff amnesics and fourteen healthy control subjects were tested on three conditions of a spatial memory test ('short delay', 'allocentric' and 'egocentric'). The task required subjects to recall the position of a single spot of light presented on a board after various delays. The 'short delay' condition tested memory over very short, unfilled intervals. The other two conditions used longer, filled delays. The allocentric condition required subjects to move to a different place around the board before recalling the position of the light. In the egocentric condition stimuli were presented in darkness, which eliminated allocentric cues. The Korsakoff amnesics were impaired at all delays of the short delay tasks, suggesting poor encoding. On the allocentric and egocentric tasks the Korsakoff amnesics showed a comparable impairment in the two conditions, which worsened with delay. This accelerated forgetting suggested that the Korsakoff amnesics also had impaired memory for allocentric and egocentric information. The patients with medial temporal lobe damage were unimpaired in the 'short delay' condition suggesting intact encoding and short-term memory of spatial information. However, they were impaired in the allocentric condition and showed accelerated loss of allocentric spatial information. In the egocentric condition, while the performance of one patient was impaired, the performance of the other was as good as controls. This result suggests that, in contrast to allocentric spatial memory, which is sensitive to medial temporal lobe damage, an intact medial temporal lobe need not be necessary for successful performance on an egocentric spatial memory task.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 94%

Section: Fig 1 -Coronal Sections From the Patients Rs Nm And An Agmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage

et al. 2000

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“…Here, too, the rat must learn to turn in the opposite direction after a nonrewarded (but formerly rewarded) trial. Thus, the Greek-cross task may be considered especially sensitive to the behavioral flexibility of the animal (McDaniel et al, 1995). Because of the reversal requirement, the inability to flexibly adjust behavior as function of changing environmental and behavioral demands should be reflected in perseverative behavior (see Clarke, Robbins, & Roberts, 2008).…”

Section: Nonspatial Assessmentmentioning

confidence: 99%

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Compton¹,

Selinger²,

Westman³

et al. 2011

Psychology & Neuroscience

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The so-called "club drug" Foxy or Methoxy Foxy (5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is a newer drug of abuse that has recently gained in popularity among recreational users as an alternative to MDMA (Ecstasy). While considerable research into the consequences of MDMA use is available, much remains unknown about the neurobiological consequences of 5-MeO-DIPT use. In the present study, beginning at 35 days of age adolescent rats were given repeated injections of 10 mg/kg of 5-MeO-DIPT, MDMA, or a corresponding volume of isotonic saline. Adult animals (135 days old) were trained and tested on a number of tasks designed to assess the impact, if any, and severity of 5-MeO-DIPT and MDMA, on a series of spatial and nonspatial memory tasks. Both the 5-MeO-DIPT-and the MDMA-treated rats were able to master the spatial navigation tests where the task included a single goal location and all groups performed comparably on these phases of training and testing. Conversely, the performance of both groups of the drug-treated rats was markedly inferior to that of the control animals on a task where the goal was moved to a new location and on a response learning task, suggesting a lack of flexibility in adapting their responses to changing task demands. In addition, in a response learning version of a learning set task, 5-MeO-DIPT rats made significantly more working memory errors than MDMA or control rats. Results are discussed in terms of observed alterations in serotonin activity in the forebrain and the consequences of compromised serotoninergic systems on cognitive processes.

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Hippocampal-parietal cortical interactions in spatial cognition

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Poucet

2000

Hippocampus

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Growing evidence suggests that the associative parietal cortex (APC) of the rat is involved in the processing of spatial information. This observation raises the issue of the respective functions of the APC and the hippocampus in spatial processing as well as of their possible interactions. In this paper, we review neuroanatomical, electrophysiological, and behavioral data that support the existence of such functional interactions. Our hypothesis is that the APC is involved in the initial combination of visuospatial information and self‐motion information necessary for the integration of egocentrically acquired information into allocentrically coded information, the latter step being completed in the hippocampus. The dialogue between the hippocampus and the APC is therefore crucial, particularly when the elaboration and/or updating of an allocentric representation depends on complex combinations of visuospatial and self‐motion information. Hippocampus 10:491–499, 2000 © 2000 Wiley‐Liss, Inc.

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Unilateral injury of posterior parietal cortex and spatial learning in hooded rats

Cited by 33 publications

References 38 publications

A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage

A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Hippocampal-parietal cortical interactions in spatial cognition

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