Unilateral Lesion of Dorsal Hippocampus Enhances Reinforcing Lateral Hypothalamic Stimulation in the Contralateral Hemisphere

Zimmermann, Petra K; Wagner, Uwe; Krauth, J.; Huston, Joseph P.

doi:10.1016/s0361-9230(97)00135-4

Cited by 14 publications

(4 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These preliminary results suggest that NVHL-induced facilitation of instrumental learning may require extensive bilateral damage, whereas sparing contralateral hippocampal inputs generally disrupts extinction learning relative to bilateral lesions. In contrast, unilateral lesions of the CA1 region in the adult rats are reported to "disinhibit" the reinforcing effects of contralateral brain stimulation reward, but do not alter extinction of this behavior (Zimmerman et al 1997). Although further study of these phenomena is warranted, it is possible that unilateral and bilateral NVH lesions produce differential developmental alterations in adults.…”

Section: Discussionmentioning

confidence: 95%

Motivational Responses to Natural and Drug Rewards in Rats with Neonatal Ventral Hippocampal Lesions An Animal Model of Dual Diagnosis Schizophrenia

Chambers

Self

2002

Neuropsychopharmacology

102

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Motivational Responses to Natural and Drug Rewards in Rats with Neonatal Ventral Hippocampal Lesions An Animal Model of Dual Diagnosis Schizophrenia

Chambers

Self

2002

Neuropsychopharmacology

102

View full text Add to dashboard Cite

“…Whereas the hippocampus has been widely shown to play a crucial role in memory (Zola-Morgan and Squire, 1990;Dolan and Fletcher, 1997), our findings suggest its functions extend beyond the purely mnemonic. Previous evidence for nonmnemonic functions include animal data showing that hippocampal lesions enhance self-stimulation responding (Zimmermann et al, 1997), increase the hedonic properties of food reward (Schmelzeis and Mittelman, 1996), and increase resistance to extinction (Jarrard et al, 1986). These findings suggest that hippocampal activity may have an inhibitory effect on experience of reward.…”

Section: Discussionmentioning

confidence: 97%

Dissociable Neural Responses in Human Reward Systems

Elliott¹,

Friston²,

2000

View full text Add to dashboard Cite

Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.

show abstract

“…Moreover, PS males show a reduction in spine density and dendritic complexity in hippocampus [20] and medial prefrontal cortex [31]. Damage to the hippocampus [21,49] or the medial prefrontal cortex [34] could display a high Gao-14 resistance to extinction in some appetitive learning situations. Thus, altered responsiveness of the HPA axis and the dopamine system in these brain regions may contribute to the behavioral deficit observed here in PS rats.…”

Section: Gao-5mentioning

confidence: 99%

Cocaine enhances resistance to extinction of responding for brain-stimulation reward in adult prenatally stressed rats

Gao

Suenaga

Osuga

et al. 2011

Behavioural Brain Research

View full text Add to dashboard Cite

The present experiment assessed whether prenatal stress (PS) can alter the ability of acute and chronic cocaine administration to increase and decrease the rewarding effectiveness of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS), and also whether PS can affect the extinction of the MFB stimulation response. Adult male offspring of female rats that received PS or no PS (nPS) were implanted with MFB stimulating electrodes, and were then tested in ICSS paradigms. In both nPS and PS offspring, acute cocaine injection decreased ICSS thresholds dose-dependently. However, the threshold-lowering effects at any dose were not significantly different between groups. There was also no group-difference in the threshold-elevating effects of chronic cocaine administration. Nevertheless, chronically drug-administered PS rats exhibited a resistance to the extinguishing of the response for brain-stimulation reward when acutely treated with cocaine, as compared to extinction without cocaine treatment. The results suggest that PS may weaken the ability for response inhibition under cocaine loading in male adult offspring.

show abstract

Unilateral Lesion of Dorsal Hippocampus Enhances Reinforcing Lateral Hypothalamic Stimulation in the Contralateral Hemisphere

Cited by 14 publications

References 61 publications

Motivational Responses to Natural and Drug Rewards in Rats with Neonatal Ventral Hippocampal Lesions An Animal Model of Dual Diagnosis Schizophrenia

Motivational Responses to Natural and Drug Rewards in Rats with Neonatal Ventral Hippocampal Lesions An Animal Model of Dual Diagnosis Schizophrenia

Dissociable Neural Responses in Human Reward Systems

Cocaine enhances resistance to extinction of responding for brain-stimulation reward in adult prenatally stressed rats

Contact Info

Product

Resources

About