Unilateral lesions of the pedunculopontine nucleus do not alleviate subthalamic nucleus-mediated anticipatory responding in a delayed sensorimotor task in the rat

Florio, Tiziana Marilena; Capozzo, Annamaria; Cellini, R; Pizzuti, G; Staderini, Enrico M.; Scarnati, Eugenio

doi:10.1016/s0166-4328(01)00248-0

Cited by 15 publications

(19 citation statements)

References 53 publications

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“…The activated area in the midbrain was located in the middle cerebellar peduncle during the imagery task. A previously published study demonstrated that the pedunculopontine nucleus region induced impaired conditioned responses, absent of global motor impairment, to salient stimuli (Florio et al 2001). This area might therefore play an important role in learning, memory, or the recollection of motor tasks.…”

Section: Discussionmentioning

confidence: 95%

Comparison Between a Real Sequential Finger and Imagery Movements: An fMRI Study Revisited

Ueno

Inoue

Matsuoka

et al. 2010

Brain Imaging and Behavior

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Recently, much discussion has been centered on the brain networks of recall, memory, and execution. This study utilized functional magnetic resonance imaging to compare activation between a simple sequential finger movement (real task) and recalling the same task (imagery task) in 15 right-handed normal subjects. The results demonstrated a greater activation in the contralateral motor and somatosensory cortex during the real task, and a higher activation in the contralateral inferior frontal cortex, ipsilateral motor, somatosensory cortex, and midbrain during the imagery task. These real task-specific areas and imagery-specific areas, including the ipsilateral motor and somatosensory cortex, are consistent with recent studies. However, this is the first report to demonstrate that the imagery-specific regions involve the ipsilateral inferior frontal cortex and midbrain. Directly comparing the activation between real and imagery tasks demonstrated the inferior frontal cortex and midbrain to therefore play important roles in cognitive feedback.

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Section: Discussionmentioning

confidence: 95%

Comparison Between a Real Sequential Finger and Imagery Movements: An fMRI Study Revisited

Ueno

Inoue

Matsuoka

et al. 2010

Brain Imaging and Behavior

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“…We speculate that attenuation of this inhibitory process may render an individual especially susceptible to the reinforcing effects of drugs or exacerbate drug addiction by leaving only the incentive motivational process intact, unchecked by the inhibitory process (Jentsch and Taylor, 1999). Indeed, STN lesions have been shown to decrease response inhibition and enhance impulsivity for a food reward (Baunez and Robbins, 1997;Brown, 1999, 2000;Florio et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Uslaner

Yang

Robinson³

2005

J. Neurosci.

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The subthalamic nucleus (STN) is traditionally thought to be involved in motor control, and dysfunction of the STN is thought to contribute to movement disorders. Here, we show that the STN also plays an important role in motivational processes and the response to drugs of abuse. Specifically, bilateral STN lesions produced a dose-dependent increase in the psychomotor-activating effects of cocaine, the rate at which animals acquired cocaine self-administration, and the motivation for cocaine assessed using a progressive ratio schedule. Furthermore, bilateral STN lesions enhanced the ability of cocaine to induce gene expression in the nucleus accumbens and caudate-putamen, two structures known to be involved in mediating the psychomotor-activating and incentive motivational effects of drugs of abuse. These findings suggest that engagement of the STN serves to dampen the psychomotor-activating and incentive motivational effects of drugs of abuse. Thus, the STN may serve as a novel target for therapeutic interventions aimed at treating drug dependence.

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“…Sections were cleared in xylene, mounted in permount and analysed by a computerised image analyser system. Slices including the PPTg were processed with either cresyl violet staining to localise electrode trajectory or NADPH-diaphorase to label ACh-containing neurons in the PPTg as previously described [49].…”

Section: Histologymentioning

confidence: 99%

Continuous stimulation of the pedunculopontine tegmental nucleus at 40Hz affects preparative and executive control in a delayed sensorimotor task and reduces rotational movements induced by apomorphine in the 6-OHDA parkinsonian rat

Capozzo¹,

Vitale²,

Mattei³

et al. 2014

Behavioural Brain Research

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Unilateral lesions of the pedunculopontine nucleus do not alleviate subthalamic nucleus-mediated anticipatory responding in a delayed sensorimotor task in the rat

Cited by 15 publications

References 53 publications

Comparison Between a Real Sequential Finger and Imagery Movements: An fMRI Study Revisited

Comparison Between a Real Sequential Finger and Imagery Movements: An fMRI Study Revisited

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Continuous stimulation of the pedunculopontine tegmental nucleus at 40Hz affects preparative and executive control in a delayed sensorimotor task and reduces rotational movements induced by apomorphine in the 6-OHDA parkinsonian rat

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