Unilateral naris closure and olfactory system development

Brunjes, Peter C.

doi:10.1016/0165-0173(94)90007-8

Cited by 211 publications

(185 citation statements)

References 97 publications

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“…When examined at the age of four weeks, the treatment led to a thinner olfactory epithelium in most regions primarily due to the reduction of immature OSNs (Figs. 2A-E), consistent with previous reports (Brunjes, 1994). This was revealed by double immunostaining with the OMP and the neural cell adhesion molecule (NCAM) antibodies.…”

Section: Sensory Deprivation Maintains a High Coexpression Frequency supporting

confidence: 91%

Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ

Tian

2008

Molecular and Cellular Neuroscience

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A fundamental belief in the field of olfaction is that each olfactory sensory neuron (OSN) expresses only one odorant receptor (OR) type. Here we report that coexpression of multiple receptors in single neurons does occur at a low frequency. This was tested by double in situ hybridization in the septal organ in which greater than 90% of the sensory neurons express one of nine identified ORs. Notably, the coexpression frequency is nearly ten times higher in newborn than in young adult mice, suggesting a reduction of the sensory neurons with multiple ORs during postnatal development. In addition, such reduction is prevented by four-week sensory deprivation or impaired apoptosis. Furthermore, the high coexpression frequency is restored following four-week naris closure performed in young adult mice. The results indicate that activity induced by sensory inputs plays a role in ensuring the one cell-one receptor rule in a subset of olfactory sensory neurons.

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Section: Sensory Deprivation Maintains a High Coexpression Frequency supporting

confidence: 91%

Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ

Tian

2008

Molecular and Cellular Neuroscience

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“…In the mouse OB, sensory input has been studied during development and in adulthood by a variety of manipulations ranging from odor deprivation to genetic silencing of ORNs (Brunjes, 1994;Zhao and Reed, 2001). Sensory input plays a regulatory role during initial wiring of the glomeruli (Kerr and Belluscio, 2006) as well as in competitive interactions between ORNs as they re-innervate existing glomeruli in adulthood (Zheng et al, 2000).…”

Section: Sensory Input Regulates the Development Of Adult-born Neuronsmentioning

confidence: 99%

Sensory Input Enhances Synaptogenesis of Adult-Born Neurons

Livneh¹,

Feinstein²,

Klein³

et al. 2009

J. Neurosci.

126

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The adult mammalian brain maintains a prominent stem cell niche in the subventricular zone supplying new neurons to the olfactory bulb. We examined the dynamics of synaptogenesis by imaging the formation and elimination of clusters of a postsynaptic marker (PSD95), genetically targeted to adult-born neurons. We imaged in vivo adult-born periglomerular neurons (PGNs) during two phases of development, immaturity and maturity. Immature PGNs showed high levels of PSD95 puncta dynamics during 12-72 h intervals. Mature PGNs were more stable compared with immature PGNs but still remained dynamic, suggesting that synaptogenesis persists long after these neurons integrated into the network. By combining intrinsic signal and two photon imaging we followed PSD95 puncta in sensory enriched glomeruli. Sensory input upregulated the development of adult-born PGNs only in enriched glomeruli. Our data provide evidence for an activity-based mechanism that enhances synaptogenesis of adult-born PGNs during their initial phases of development.

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“…Notably, no THϩ PGNs could be observed among the few PGNs detectable after transduction with Dlx2-Engrailed (data not shown). Given the fact that TH-expression is known to increase with maturation (Brunjes, 1994;Winner et al, 2002;Hack et al, 2005), we examined whether Dlx2 overexpression had only accelerated the expression of TH or had indeed permanently increased the proportion of this neuronal subtype. Consistent with the gradual maturation of TH expression, 8 weeks after control injections into the RMS, the proportion of THϩ neurons had increased to 29 Ϯ 3% (from 7% after 3 weeks).…”

Section: Dlx2 Promotes Dopaminergic Pgn Fate In the Adult Obmentioning

confidence: 99%

A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb

Brill¹,

Snapyan²,

Wohlfrom³

et al. 2008

Journal of Neuroscience

189

222

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Distinct olfactory bulb (OB) interneurons are thought to become specified depending on from which of the different subregions lining the lateral ventricle wall they originate, but the role of region-specific transcription factors (TFs) in the generation of OB interneurons diversity is still poorly understood. Despite the crucial roles of the Dlx family of TFs for patterning and neurogenesis in the ventral telencephalon during embryonic development, their role in adult neurogenesis has not yet been addressed. Here we show that in the adult brain, Dlx 1 and Dlx2 are expressed in progenitors of the lateral but not the dorsal subependymal zone (SEZ), thus exhibiting a striking regional specificity. Using retroviral vectors to examine the function of Dlx2 in a cell-autonomous manner, we demonstrate that this TF is necessary for neurogenesis of virtually all OB interneurons arising from the lateral SEZ. Beyond its function in generic neurogenesis, Dlx2 also plays a crucial role in neuronal subtype specification in the OB, promoting specification of adult-born periglomerular neurons (PGNs) toward a dopaminergic fate. Strikingly, Dlx2 requires interaction with Pax6, because Pax6 deletion blocks Dlx2-mediated PGN specification. Thus, Dlx2 wields a dual function by first instructing generic neurogenesis from adult precursors and subsequently specifying PGN subtypes in conjunction with Pax6.

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Unilateral naris closure and olfactory system development

Cited by 211 publications

References 97 publications

Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ

Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ

Sensory Input Enhances Synaptogenesis of Adult-Born Neurons

A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb

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