Unilateral Neurogenic Pulmonary Oedema and Severe Left Ventricular Dysfunction Secondary to Acute Multiple Sclerosis Exacerbation

Cardiovascular Dysfunction in Multiple Sclerosis

“…[34][35][36][37][38][39][40] The relationship between baseline disability and associated LV function in such patients remains unclear, as data are limited. Some studies have found no correlation between EDSS score and LV function, 35 whereas others have demonstrated impaired baseline LV function in MS patients with higher EDSS scores.…”

Pulmonary Haemorrhage Associated with Neonatal Neurological Disease

“…4,5 Neurological insults may lead to cardiopulmonary sequelae as a result of interplay between enhanced sympathetic tone, inflammatory cytokines and other factors. 5 However, this association has not been tested in neonates.…”

Neurocardiogenic Pulmonary Oedema: Initial Presentation of Multiple Sclerosis

“…normal JVP and PCWP). Other cases reported normal cardiac Neurocardiogenic Pulmonary Oedema function [4,6,9], suggesting a primary neurogenic mechanism. Neurogenic pulmonary oedema is thought to occur in part from alterations in central autonomic outflow that generate increased pulmonary hydrostatic pressure and or capillary permeability [10].…”

“…Several case reports have shown new brainstem or cervical cord lesions associated with APO in relapses of MS [1][2][3][4][5]. Relapses with APO were typically preceded within hours or days by upper limb parasthesias, headache or visual disturbance [5].…”

“…Initial echocardiogram showed severe LV basal segment hypokinesis, with complete recovery after three days. Some case reports of APO in MS have shown global [4,7] or segmental wall motion abnormalities [5,8] but the mechanisms are poorly understood. Acute LV dysfunction in the absence of obstructive coronary disease is seen following acute neurological insults including subarachnoid haemorrhage (SAH) and is a unique manifestation of acute stress in Takotsubo cardiomyopathy [11,12].…”