Unilateral optical nerve hypoplasia in a Beagle dog

Negishi, Hisanari; Hoshiya, Toru; Tsuda, Y; Doi, Kunio; Kanemaki, Nobuyuki

doi:10.1258/la.2007.007033

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Garcia da Silva et al identified also this abnormality in a group of dogs with a median age of diagnosis of 16.1 months, being mainly bilateral in presentation 61 . Negishi et al also reported a case of optic nerve hypoplasia in a 6‐month‐old Beagle 62 …”

Section: Discussionmentioning

confidence: 86%

Congenital ocular malformations in dogs and cats: 123 cases

Saraiva

Delgado

2020

Veterinary Ophthalmology

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Objective Provide epidemiological data regarding the prevalence of congenital ocular malformations in dogs and cats. Animals studied A population of 32 974 dogs and 13 977 cats that presented for consultation at the veterinary teaching hospital. Procedures Medical records from 2011 to 2018 were reviewed. A retrospective and prospective epidemiological clinical study addressing congenital ocular malformations was conducted. Signalment, medical history, reason for presentation, clinical findings, vision impairment, and treatment options were analyzed. Results From the total of cases analyzed, 103 dogs (0.3%) and 20 cats (0.1%) met the inclusion criteria. The majority of dogs were mixed breed, the most common breed being the French Bulldog, while the majority of cats were European domestic shorthair. The median age of diagnosis was 12 months for dogs and 6 months for cats. Sex predisposition was not found. The most frequently identified abnormalities were as follows: congenital cataract (dogs: 31.1%; cats: 30.0%), microphthalmia (dogs: 35.0%, cats: 25.0%), and persistent pupillary membrane (dogs: 27.2%, cats: 40.0%). Some of the concurrently observed malformations were significantly associated. A statistically significant association was found between ocular dermoids and the French Bulldog breed (P < .001). Conclusions Even though congenital ocular malformations are uncommon, knowledge about their prevalence is important, since they can cause vision impairment or even blindness. Moreover, some human ocular disease phenotypes are similar to the ones presented by dogs and cats, so they can be used as models to investigate pathophysiology and therapeutic approaches.

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Section: Discussionmentioning

confidence: 86%

Congenital ocular malformations in dogs and cats: 123 cases

Saraiva

Delgado

2020

Veterinary Ophthalmology

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“…3 In a naturally occurring animal model of canine ONH, histologic studies suggested that although NFL and retinal ganglion cell layer thickness were hypoplastic, the outer retinal layers were preserved. 4 Macular hypoplasia has also been reported in other optic neuropathies such as the morning glory disc anomaly, 5 as well as in cases of acquired optic neuropathy associated with non-arteritic ischemic optic neuropathy, optic nerve head drusen, systemic lupus erythematosus, and pseudotumor cerebri. 6 In these optic neuropathies, cone photoreceptors displayed structural changes in the presence of permanent damage to the overlying inner retina layers (retinal ganglion cell-NFL-inner plexiform).…”

Section: Discussionmentioning

confidence: 95%

Macular Thinning Associated with Unilateral Optic Nerve Hypoplasia

Hoang¹,

Chau²,

Shahidi³

et al. 2011

Ophthalmic Surg Lasers Imaging

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The authors present the case of an 8-year-old boy with a long-term diagnosis of unilateral optic nerve hypoplasia (ONH) of unknown cause in the right eye. Spectral- domain optical coherence tomography (SD-OCT) of the central macula was consistent with hypoplasia greatest in the inner retinal layers, but also involving the outer retinal layers when compared with the unaffected contralateral eye. Although ONH is commonly associated with hypoplasia of the nerve fiber and ganglion cell layers, it can also be associated with hypoplasia of other layers in the inner and outer retina, including the outer nuclear and photoreceptor inner/outer segment layers, as evidenced by SD-OCT.

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“…Localized retinal atrophy of the nerve fiber layer and the inner nuclear layer to retinal atrophy in all layers was observed in the retina. In cases of humans and dogs showing hypoplasia of the optic nerve, a decrease in the retinal ganglion cell layer and a thinning of the nerve fiber layer have been observed [14][15][16] . Therefore, this characteristic retinal thinning was probably attributable to optic nerve hypoplasia.…”

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confidence: 98%

Porencephaly with an optic organ abnormality in a beagle dog

et al. 2022

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A female TOYO beagle dog showed porencephaly and visual organ abnormalities. At necropsy, there was a cavity filled with cerebrospinal fluid in the right cerebral hemisphere and an adhesion area between the cerebral cortex and the skull, which was partially thickened. Additionally, the right optic nerve showed a slight decrease in diameter. Histopathological examination revealed increased glial fibers and collagen fibers, hemosiderin deposition, and an increased number of microglia in the adhesion area, along with a marked reduction of the cerebral parenchyma. In the right eyeball, the retina and optic nerve showed focal atrophy in the nerve fiber layer and inner granular layer to full retinal atrophy and hypoplasia of the myelinated nerve fibers, respectively.Electron microscopic examination revealed hypoplasia of the myelin sheath of nerve fibers in the right optic nerve. This is an extremely rare case of porencephaly and congenital optic nerve hypoplasia, along with independent retinal thinning.

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Unilateral optical nerve hypoplasia in a Beagle dog

Cited by 6 publications

References 6 publications

Congenital ocular malformations in dogs and cats: 123 cases

Congenital ocular malformations in dogs and cats: 123 cases

Macular Thinning Associated with Unilateral Optic Nerve Hypoplasia

Porencephaly with an optic organ abnormality in a beagle dog

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